现代医学疾病阶段病理生理状态与态靶辨治关系

Relationship Between Pathophysiological State of the Disease Stage and State-Target Differentiation and Treatment in Modern Medicine

态靶辨治理论体系是仝小林院士提出的现代中西医结合创新诊疗体系。态是在现代医学疾病分期基础上的阶段核心病机与外在“证”的有机融合体的高度概括。靶是对疾病本身、临床症状以及态下对应的理化指标共同形成的治疗靶点的整合。现代医学疾病的阶段病理生理状态,实际上就是中医核心病机的外在表象和确立依据。态靶辨治理论体系下,通过分析疾病所处的特定阶段的病理生理状态(态)及其背后明确的客观指标(靶),旨在以态靶同调策略为核心,制定出针对性的综合治疗方案。通过对现代疾病“病—类—期—态—证—靶”诊疗模式进行重构,进一步明确了现代医学疾病的阶段病理生理状态与态靶辨治的对应关系。本文通过梳理肝炎—肝硬化—肝癌转化模型、新冠病毒感染“郁—闭—脱—虚”病程演变、流行性出血热“热毒—厥脱—肾损—正虚”分期,以态靶辨治理论对现代疾病的阶段病理生理状态进行分析解读,并以某一阶段病理生理状态为“靶”提供临床治疗靶向性和有效性。

The theoretical system of state-target differentiation and treatment is an innovative diagnosis and treatment system of modern integrated Chinese and Western medicine proposed by Academician Tong Xiao-lin.The state is a high-level summary of the organic fusion of the stage,core pathogenesis and external"syndrome"on the basis of modern medical disease staging.The target is the integration of the therapeutic target formed by the disease itself,clinical symptoms,and the corresponding physical and chemical indicators under the state.The pathophysiological state of modern medical diseases is actually the external appearance and establishment basis of the core pathogenesis of Chinese medicine.Under the theoretical system of state-target discrimination,by analyzing the pathophysiological state(state)of the specific stage of the disease and the clear objective indicators(target)behind it,the aim is to formulate a targeted comprehensive treatment plan with the state-target homology strategy as the core.By reconstructing the diagnosis and treatment mode of"diseasekind-stage-state-pattern-target"of modern diseases,the correspondence between the pathophysiological state of modern medical diseases and the treatment of state targets was further clarified.In this paper,the author analyzed and interpreted the pathophysiological state of modern diseases by combing the transformation model of hepatitiscirrhosis-liver cancer,the evolution of the course of"depression-closure-detachment-deficiency"of new coronavirus infection,and the staging of"fever-toxin-syncope-renal damage-positive deficiency"of epidemic hemorrhagic fever,and the pathophysiology of a certain stage was used as the"target"to provide clinical treatment targeting and effectiveness.