中药及其有效成分防治痛风性关节炎作用机制研究进展

Exploration Progress of the Mechanism of Gouty Arthritis Based on Modern Medicine

痛风性关节炎(gouty arthritis,GA)是一种以尿酸升高为特征的代谢性疾患,随着现代生活方式以及饮食结构的发展变化,该病逐渐呈现出低龄化、高致残率的发展趋势,严重影响着人类的身心健康,因此积极有效的防治尤为关键。目前关于GA的治疗方式主要以抑制尿酸生成为主,其能够在一定程度上改善患者的临床症状,但是在治疗的过程中易导致胃肠道等不良反应,加之治疗周期漫长,在一定程度上导致患者的依从性较差,给治疗带来较大困难。中医药凭借其安全有效、不良反应少的优势在治疗痛风中占据重要的地位,随着网络药理学以及分子生物学的不断发展,中医药治疗优势逐渐突显,治疗效果深受患者及临床工作者的认可。研究发现中医药可通过抑制机体炎症反应、抑制氧化应激、减少尿酸生成以及多条信号通路途径来达到防治痛风性关节炎的目的,同时通过中医的整体观念以及辨证论治进而达到对痛风性关节炎的精准化治疗。该文就中药防治痛风性关节炎作用机制作一综述,以期为中药防治痛风性关节炎临床应用提供新方法和新思路。

Gout arthritis(GA)as a kind of metabolic diseases characterized by the uric acid rise,with the development of modern lifestyle and diet structure,the disease gradually presents a low,the development trend of high disability,seriously affect the human body and mind and health,so positive and effective treatment about GA is mainly to inhibit uric acid generation.It can improve the clinical symptoms of patients to some extent,but in the process of treatment is easy to lead to gastrointestinal adverse reactions,combined with the treatment cycle long to a certain extent,lead to the dependence of the patients is poor,bring great difficulties to treatment.TCM plays an important role in the treatment of gout with its advantages of safety and effectiveness and less adverse effects,with the continuous development of network pharmacology as well as molecular biology,the advantages of TCM treatment are gradually magnified,the treatment effect is deeply favored by patients and clinical workers.Studies have found that TCM can achieve the purpose of preventing and controlling gout arthritis by inhibiting the body inflammatory response,inhibiting oxidative stress,reducing uric acid production and multiple signaling pathways,at the same time,through the overall concept of traditional Chinese medicine and syndrome differentiation to achieve the precise treatment of gouty arthritis.To summarize the mechanism of gouty arthritis,in order to provide new methods and new ideas for the clinical application of traditional Chinese medicine in the prevention and treatment of gout arthritis.