降乳方联合溴隐亭治疗特发性高催乳素血症月经后期临床研究

Clinical Research of Jiangru Decoction(降乳方)Combined with Bromocriptine in the Treatment of Idiopathic Hyperprolactinemia-induced Delayed Menorrhea

目的研究降乳方联合溴隐亭对特发性高催乳素(prolactin,PRL)血症月经后期的疗效。方法将60例特发性高PRL血症月经后期患者随机分为治疗组(30例)和对照组(30例),治疗组给予降乳方加溴隐亭,对照组给予溴隐亭,比较两组治疗后的血清PRL、雌二醇(estradiol,E2)、卵泡刺激素(follicle-stimulating hormone,FSH)、黄体生成素(luteinizing hormone,LH)水平,月经积分,中医证候积分,基础体温(basal body temperature,BBT),疗效,用药不良反应及停药后复发率。结果治疗后,两组血清PRL水平均降低,E2、FSH、LH水平及BBT双向率均升高,差异有统计学意义(P<0.01);且治疗组月经积分及中医证候积分均低于对照组,差异有统计学意义(P<0.01);治疗组中医证候疗效总有效率96.67%高于对照组的80%,总体疗效的有效率96.67%高于对照组的73.33%,差异均具有统计学意义(P<0.05);治疗组不良反应发生率为6.67%,低于对照组的26.67%,且治疗组复发率为6.67%,低于对照组的37.04%,差异均具有统计学意义(P<0.05)。结论降乳方联合溴隐亭可使高PRL血症月经后期患者体内PRL水平降低,使E2、FSH、LH水平升高,使中医证候积分降低,调整月经周期,提高排卵率,提高临床疗效,用药安全性高,停药后复发率低。

Objective To study the curative effect of Jiangru Decoction(降乳方)combined with bromocriptine on the idiopathic hyperprolactinemia-induced delayed menorrhea.Methods The 60 patients of idiopathic hyperprolactinemia-induced delayed menorrhea were randomized into 30 patients in the treatment group and 30 patients in the control group.The control group was given bromocriptine,and the treatment group was given Jiangru Decoction plus bromocriptine.Serum levels of PRL,estradiol(E2),follicle stimulating hormone(FSH),luteinizing hormone(LH),menstrual score,TCM syndrome score,basal body temperature(BBT),therapeutic effect,adverse reactions and recurrence rate after drug withdrawal were observed after treatment.Results After treatment,serum PRL levels in 2 groups were decreased,E2,FSH,LH levels and BBT bidirectional rate were increased,the difference was statistically significant(P<0.01);Moreover,the menstrual score and traditional Chinese medicine symptom score in the treatment group were lower than those in the control group,with a statistically significant difference(P<0.01).The total effective rate of herbal symptomatic efficacy in the treatment group was 96.67%higher than that of 80%in the control group,and the total effective rate of 96.67%was higher than that of 73.33%in the control group,and the difference was statistically significant in both of them(P<0.05).The incidence of adverse reactions in the treatment group was 6.67%,which was lower than 26.67%in the control group,and the recurrence rate in the treatment group was 6.67%,which was lower than 37.04%in the control group,with statistical significance(P<0.05).Conclusion Jiangru Decoction combined with bromocriptin can reduce the level of PRL,increase the level of E2,FSH and LH in the patients'body of whom suffer from the idiopathic hyperprolactinemia-induced delayed menorrhea,reduce the TCM symptom score,adjust the menstrual cycle,improve clinical efficacy,Improve ovulation rate,have high clinical safety and low recurrence rate after stopping taking medicine.