苯巴比妥联合地西泮治疗小儿惊厥的临床效果及对免疫功能的影响

Clinical effect of phenobarbital combined with diazepam in the treatment of children with convulsion and its influence on immune function

目的探讨苯巴比妥联合地西泮治疗小儿惊厥的临床效果及对免疫功能的影响。方法选取2021年9月至2022年9月我院收治的74例惊厥患儿为研究对象,随机将其分为对照组和观察组,各37例。对照组采用地西泮治疗,观察组在对照组基础上加苯巴比妥治疗。比较两组的血清学指标、免疫功能指标及恢复时间相关指标。结果治疗前,两组的S-100β、脑源性神经营养因子(BDNF)、神经元特异性烯醇化酶(NSE)水平无显著差异(P>0.05);治疗后,观察组的S-100β、BDNF、NSE水平低于对照组,差异具有统计学意义(P<0.05)。治疗前,两组的免疫球蛋白A(IgA)、免疫球蛋白G(IgG)、免疫球蛋白M(IgM)水平无显著差异(P>0.05);治疗后,观察组的IgA、IgG、IgM水平低于对照组,差异具有统计学意义(P<0.05)。观察组的惊厥停止时间、平均起效时间、住院时间、体温恢复时间短于对照组,差异具有统计学意义(P<0.05)。结论苯巴比妥联合地西泮治疗小儿惊厥的效果显著,可调节血清学指标及免疫功能,缩短住院时间,改善预后,值得临床借鉴应用及推广。

Objective To explore the clinical effect of phenobarbital combined with diazepam in the treatment of children with convulsion and its influence on immune function.Methods A total of 74 children with convulsion admitted in our hospital from September 2021 to September 2022 were selected as the research objects and randomly divided into control group and observation group,with 37 cases in each group.The control group was treated with diazepam,and the observation group was treated with phenobarbital on the basis of the control group.The serological indexes,immune function indexes and recovery time related indexes of the two groups were compared.Results Before treatment,there were no significant differences in the levels of S-100β,brain-derived neurotrophic factor(BDNF)and neuron specific enolase(NSE)between the two groups(P>0.05);after treatment,the levels of S-100β,BDNF and NSE in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).Before treatment,there were no significant differences in the levels of immunoglobulin A(IgA),immunoglobulin G(IgG)and immunoglobulin M(IgM)between the two groups(P>0.05);after treatment,the levels of IgA,IgG and IgM in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).The convulsion stop time,average onset time,hospitalization time and body temperature recovery time in the observation group were shorter than those in the control group,and the differences were statistically significant(P<0.05).Conclusion Phenobarbital combined with diazepam is effective in the treatment of children with convulsion,it can regulate serological indexes and immune function,shorten hospitalization time and improve prognosis,which is worthy of clinical reference application and promotion.