补肾促孕方联合来曲唑治疗多囊卵巢综合征不孕症的可行性及对性激素的影响

Feasibility of Bushen Cuyun recipe combined with letrozole in the treatment of polycystic ovary syndrome and infertility and its effect on sex hormones

目的分析补肾促孕方联合来曲唑治疗多囊卵巢综合征不孕症的可行性及对性激素的影响。方法选取2021年1月至12月西安市高陵区妇幼保健院收治的80例多囊卵巢综合征不孕症患者作为研究对象,随机将其分为来曲唑组(40例,来曲唑治疗)和中西结合组(40例,补肾促孕方联合来曲唑治疗)。比较两组患者的治疗效果。结果中西结合组的治疗总有效率显著高于来曲唑组,差异具有统计学意义(P<0.05)。治疗后,中西结合组的促黄体生成素(LH)、睾酮(T)、泌乳素(PRL)水平显著低于来曲唑组,促卵泡激素(FSH)、雌激素(E2)、孕激素(P)水平显著高于来曲唑组,差异具有统计学意义(P<0.05)。治疗后,中西结合组的优质卵泡生成率显著高于来曲唑组,阻力指数(RI)、搏动指数(PI)显著低于来曲唑组,子宫内膜厚度、卵巢体积显著大于来曲唑组,差异具有统计学意义(P<0.05)。两组的不良反应总发生率比较,差异无统计学意义(P>0.05)。结论补肾促孕方联合来曲唑治疗多囊卵巢综合征不孕症的临床效果显著,且未增加不良反应发生率。

Objective To analyze the feasibility of Bushen Cuyun recipe combined with letrozole in the treatment of polycystic ovary syndrome and infertility and its effect on sex hormones.Methods A total of 80 infertility patients with polycystic ovary syndrome admitted in Xi'an Gaoling District Maternal and Child Health Care Hospital from January to December 2021 were selected as the research objects.The patients were randomly divided into letrozole group(40 cases,treated with letrozole)and Chinese and western combination group(40 cases,treated with Bushen Cuyun recipe combined with letrozole).The therapeutic effects of the two groups of patients were compared.Results The total effective rate of treatment in the Chinese and western combination group was significantly higher than that in the letrozole group,and the difference was statistically significant(P<0.05).After treatment,the levels of luteinizing hormone(LH),testosterone(T)and prolactin(PRL)in the Chinese and western combination group were significantly lower than those in the letrozole group,the levels of follicle-stimulating hormone(FSH),estrogen(E2)and progesterone(P)were significantly higher than those in the letrozole group,and the differences were statistically significant(P<0.05).After treatment,the high-quality follicle formation rate in the Chinese and western combination group was significantly higher than that in the letrozole group,resistance index(RI)and pulse index(PI)were significantly lower than those in the letrozole group,endometrial thickness and ovarian volume were significantly greater than those in the letrozole group,and the differences were statistically significant(P<0.05).There was no significant difference in the total incidence of adverse reactions between the two groups(P>0.05).Conclusion Bushen Cuyun recipe combined with letrozole has a significant clinical effect in the treatment of polycystic ovary syndrome and infertility,and it does not increase the incidence of adverse reactions.