肠巨噬细胞在先天性巨结肠相关性小肠结肠炎中的研究进展

Advancedresearches of intestinal macarcorpohpahgaeg ieni nHHirisrscchhsspprurng disease associated enterocolitis

先天性巨结肠是以肠神经峭细胞未能在胚胎发育期间增殖和迁移至结肠,或者结肠神经峭细胞异常增殖和凋亡为特点的一种疾病,先天性巨结肠患儿正常的肠蠕动消失、粪便淤积在肠管内,从而导致各种并发症的发生。其中,先天性巨结肠相关性小肠结肠炎(Hirchsprung-associated enterocolitis,HAEC)是最常见的一种并发症,也是导致患儿死亡的主要原因之一,可发生于整个患病周期。目前关于HAEC的病理生理学过程仍不甚清楚,深入的相关研究发现肠巨噬细胞在抵抗和促进肠道炎症的过程中发挥着极其重要的作用。其表型可以在不同诱导因素下发生不同变化,包括促炎性细胞因子释放的M1型巨噬细胞和抗炎细胞因子释放的M2型巨噬细胞,这些巨噬细胞深入参与到HAEC的发生发展中。本文就与肠巨噬细胞相关的HAEC发病机制的研究进展做一综述,为后续相关研究提供参考。

Hirschsprung disease is a disease in which enteric nerve crick cells fail to invade,proliferate,and migrate to the colon during embryonic development,or in which colonic nerve crick cells proliferate and apoptosis abnormally,resulting in the loss of normal bowel movements and the accumulation of feces in the intestinal canal,leading to various complications.Hirschsprung associated enterocolitis(HAEC)is one of the most common complications of Hirschsprung disease and is one of the leading causes of death in children,which can occur throughout the disease cycle.The pathophysiology of HAEC is still poorly understood,but as research has progressed,it has been found that intestinal macrophages play an important role in resisting and promoting intestinal inflammation,and that their phenotype can change in response to different inducing factors and exhibit multiple functions,including M1 macrophages,which promote the release of inflammatory factors,and M2 macrophages,which are anti-inflammatory factors,and that these macrophages are deeply involved in the development of HAEC.In this paper,we review the progress of the pathogenesis of intestinal macrophage-associated HAEC and provide a reference for related research.