西格列汀联合达格列净治疗2型糖尿病临床观察

Clinical Observation of Sitagliptin Combined with Dapagliflozin in the Treatment of Type 2 Diabetes Mellitus

目的探讨西格列汀联合达格列净治疗2型糖尿病(T2DM)的临床疗效。方法选取海南省第二人民医院2021年1月至2023年1月收治的T2DM患者108例,按随机数字表法分为观察组和对照组,各54例。两组患者均予达格列净片口服,观察组患者加服磷酸西格列汀片。两组均持续治疗2个月。结果治疗后两组患者的空腹血糖、餐后2 h血糖、糖化血红蛋白水平均显著降低;内脏脂肪特异性丝氨酸蛋白酶抑制剂(vaspin)、空腹胰岛素水平及胰岛素抵抗指数均显著降低,胰岛β细胞功能指数显著升高;白细胞介素4、白细胞介素6、肿瘤坏死因子-α水平均显著降低(P<0.05);且观察组上述指标改善均更显著(P<0.05)。两组患者不良反应发生率无显著差异(P>0.05)。结论西格列汀联合达格列净治疗T2DM,能显著改善患者的血糖、vaspin水平及胰岛功能,且可减轻炎性反应。

Objective To investigate the clinical efficacy of sitagliptin combined with dapagliflozin in the treatment of type 2 diabetes mellitus(T2DM).Methods A total of 108 patients with T2DM admitted to the Second People′s Hospital of Hainan from January 2021 to January 2023 were selected and randomly divided into the observation group and the control group,with 54 cases in each group.The patients in the two groups were given oral Dapagliflozin Tablets,on this basis,the patients in the observation group were given Sitagliptin Phosphate Tablets.Both groups received continuous treatment for two months.Results After treatment,the fasting blood glucose(FBG),2-hour postprandial blood glucose(2 hPG)and glycosylated hemoglobin(HbAlC)levels in the two groups significantly decreased;the visceral adipose specific serine protease inhibitor(vaspin),fasting insulin(FINS)levels and homeostasis model assessment for insulin resistance(HOMA-IR)significantly decreased,while the homeostatic model assessment ofβ-cell function(HOMA-β)significantly increased;the interleukin-4(IL-4),interleukin-6(IL-6)and tumor necrosis factor-α(TNF-α)levels significantly decreased(P<0.05);the above indicators in the observation group were significantly better(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion Sitagliptin combined with dapagliflozin can significantly improve the blood glucose,vaspin level and pancreatic islet function in patients with T2DM,and can also alleviate inflammatory reactions.