沙利度胺联合多西环素治疗玫瑰痤疮的临床研究

Clinical study of thalidomide combined with doxycycline in treatment of rosacea

目的探讨沙利度胺片联合盐酸多西环素片治疗Ⅰ、Ⅱ型玫瑰痤疮的临床疗效。方法选择2023年1月—2023年6月在皖南医学院第一附属医院(弋矶山医院)、南阳市中心医院皮肤科门诊就诊的80例Ⅰ、Ⅱ型玫瑰痤疮患者作为研究对象,所有患者按照随机数字表法随机分为对照组和治疗组,每组40例。对照组口服盐酸多西环素片,0.1 g/次,2次/d;治疗组在对照组治疗的基础上口服沙利度胺片,50 mg/次,2次/d。两组均连续治疗2个月。比较两组的临床疗效、面部症状改善情况和血清因子水平。结果治疗后,对照组和治疗组总有效率分别为70.00%、90.00%,组间比较差异显著(P<0.05)。治疗后,两组患者红斑和毛细血管扩张、丘疹、脓疱、瘙痒评分均显著降低(P<0.05),且治疗组患者红斑和毛细血管扩张、丘疹、脓疱、瘙痒评分低于对照组(P<0.05)。治疗后,两组患者血清中白细胞介素-17(IL-17)、肿瘤坏死因子-α(TNF-α)和血管内皮生长因子(VEGF)水平均显著降低(P<0.05),且治疗组血清中IL-17、TNF-α和VEGF水平低于对照组(P<0.05)。结论沙利度胺片联合盐酸多西环素片治疗Ⅰ、Ⅱ型玫瑰痤疮有效性较高,能明显改善患者的面部症状,缓解机体的炎症状态。

Objective To investigate the clinical efficacy of Thalidomide Tablets combined with doxycycline in treatment of type I and type II rosacea.Methods A total of 80 patients with type I,II rosacea in Nanyang Central Hospital and The First Affiliated Hospital of Wannan Medical College(Yijishan Hospital)were included from January 2023 and June 2023 and divided into control group(40 cases)and treatment group(40 cases),respectively.Patients of the control group were po administered with Doxycycline Hyclate Tablets,0.1 g/time,twice daily.Patients of the treatment group were po administered with Thalidomide Tablets on the basis of the control group,50 mg/time,twice daily.Patients of both groups were treated for 2 months.The clinical efficacy,facial symptoms,and serum factor levels were compared between two groups.Results After treatment,the total effective rate of control group and treatment group was 70.00% and 90.00%,respectively,with significant difference between groups(P<0.05).The scores of facial erythema,telangiectasia,papules,pustules,and pruritus in two groups after treatment were significantly decreased(P<0.05).Compared with the control group,the scores of facial erythema,telangiectasia,papules,pustules,and pruritus in the treatment group were significantly decreased,with a statistical significance(P<0.05).After treatment,the serum levels of IL-17,TNF-α,and VEGF in two groups were significantly decreased,and the serum levels of IL-17,TNF-α,and VEGF in treatment group were significantly lower than those in the control group,with a statistical significance(P<0.05).Conclusion Thalidomide Tablets combined with Doxycycline Hyclate Tablets has a significant clinical efficacy in treatment of type I,II rosacea,and can obviously improve the facial symptoms of patients,and relieve the inflammatory state of the body.