一清片联合奥硝唑治疗智齿冠周炎的临床研究

Clinical study of Yiqing Tablets combined with ornidazole in treatment of pericoronitis of wisdom teeth

目的探讨一清片联合奥硝唑片治疗智齿冠周炎的临床效果。方法选取2022年1月—2023年10月安徽医科大学附属口腔医院就诊的112例智齿冠周炎患者,参考随机数字表法分成对照组和治疗组,每组各56例。对照组给予奥硝唑片治疗,1片/次,1次/d。治疗组在对照组治疗基础上口服一清片,4片/次,3次/d。两组患者均治疗10 d。观察两组的临床疗效,比较两组治疗前后视觉模拟量表(VAS)评分、口腔健康影响程度量表(OHIP-14)评分、冠周炎相关指标、龈沟液炎症因子的变化情况。结果治疗后,治疗组总有效率是96.43%,显著高于对照组82.14%(P<0.05)。治疗后,两组VAS和OHIP-14评分均显著降低(P<0.05),同时治疗后治疗组评分减少更显著(P<0.05)。治疗后,两组牙龈指数(GI)、菌斑指数(PLI)、龈沟出血指数(SBI)评分显著降低(P<0.05);治疗后治疗组冠周炎相关指标降低更显著(P<0.05)。治疗后,两组患者龈沟液降钙素原(PCT)和C反应蛋白(CRP)水平明显降低(P<0.05);治疗后,治疗组龈沟液PCT和CRP水平低于对照组(P<0.05)。结论一清片联合奥硝唑片治疗智齿冠周炎的临床效果显著,能减轻患者的疼痛,改善冠周炎相关症状和生活质量及抑制炎症反应。

Objective To investigate the efficacy of Yiqing Tablets combined with Ornidazole Tablets in treatment of pericoronitis of wisdom teeth.Methods A total of 112 patients with pericoronitis of wisdom teeth treated in Affiliated Stomatology Hospital of Anhui Medical University from January 2022 to October 2023 were selected and divided into control group and treatment group according to random number table method,with 56 cases in each group.Patients in the control group were given Ornidazole Tablets,1 tablet/time,once daily.Patients in the treatment group were po administered with Yiqing Tablets on the basis of the control group,4 tablet/time,three times daily.Both groups were treated for 10 d.The clinical effects of the two groups were observed,and the changes of visual analogue scale(VAS)scores,Oral health Impact Scale(OHIP-14)scores,pericoronitis related indicators and gingival crevicular fluid inflammatory factors before and after treatment were compared between two groups.Results After treatment,the total effective rate of treatment group was 96.43%,which was significantly higher than that of control group 82.14%(P<0.05).After treatment,VAS and OHIP-14 scores in both groups were significantly decreased(P<0.05),and the scores in the treatment group were significantly decreased after treatment(P<0.05).After treatment,the scores of gingival index(GI),plaque index(PLI)and gingival crevicular bleeding index(SBI)were significantly decreased in two groups(P<0.05).After treatment,the related indexes of pericoronitis in the treatment group were significantly decreased(P<0.05).After treatment,the levels of procalcitonin(PCT)and C-reactive protein(CRP)in gingival crevicular fluid were significantly decreased in two groups(P<0.05).After treatment,the levels of PCT and CRP in gingival crevicular fluid in treatment group were lower than those in control group(P<0.05).Conclusion Yiqing Tablets combined with ornidazole has significant clinical effect in treatment of pericoronitis of wisdom teeth,and can reduce the pain,improve the symptoms of pericoronitis and the quality of life,which can inhibit the inflammatory response.