华蟾素胶囊联合TP方案对晚期卵巢癌患者Th1/Th2细胞因子、血管生长因子及细胞凋亡调控因子的影响

Effect of Huachansu Capsule Combined with TP Regimen on Th1/Th2 Cytokines,Vascular Growth Factor and Apoptosis Regulatory Factors in Patients with Advanced Ovarian Cancer

目的:观察华蟾素胶囊联合紫杉醇联合铂类药物(TP)方案对晚期卵巢癌患者辅助T细胞(Th)/1Th2细胞因子、血管生长因子及细胞凋亡调控因子的影响。方法:按照随机数字表法将102例晚期卵巢癌患者分为研究组51例(华蟾素胶囊联合TP方案化疗)和对照组51例(TP方案化疗)。对比两组临床总有效率、血管生长因子、血清Th1/Th2细胞因子、细胞凋亡调控因子。结果:与对照组相比,研究组的临床总有效率更高(86.27%vs 62.75%,P<0.05)。治疗后,研究组γ-干扰素(IFN-γ)、白细胞介素-2(IL-2)、Bcl-2相关X蛋白(Bax)较对照组更高,白细胞介素-6(IL-6)、白细胞介素-4(IL-4)较对照组更低(P<0.05)。治疗后,研究组血管内皮生长因子(VEGF)、成纤维细胞生长因子(bFGF)、内皮细胞特异性分子-1(ESM-1)、血管生成素-2(Ang-2)、B细胞淋巴瘤-2(Bcl-2)、生存素(Survivin)、Bcl-2结合抗凋亡基因-1(Bag-1)较对照组更低(P<0.05)。结论:华蟾素胶囊联合TP方案治疗可通过抑制肿瘤血管生成、促进肿瘤细胞凋亡、调节免疫功能等方面来阻止晚期卵巢癌患者的疾病进展。

Objective:To observe the effect of huachansu capsule combined with paclitaxel and platinum drugs(TP)regimen on T helper cell(Th)/1Th2 cytokines,vascular growth factor and apoptosis regulatory factors in patients with advanced ovarian cancer.Methods:According to the random number table method,102 patients with advanced ovarian cancer were divided into study group of 51cases(huachansu capsule combined with TP regimen chemotherapy)and control group of 51 cases(TP regimen chemotherapy).The total clinical effective rate,vascular growth factor,serum Th1/Th2 cytokines,and apoptosis regulatory factors were compared between two groups.Results:Compared with the total clinical effective rate in control group,the total effective rate in study group was higher(86.27%vs62.75%,P<0.05).After treatment,the levels ofγ-interferon(IFN-γ),interleukin-2(IL-2)and Bcl-2 related X protein(Bax)in study group were higher than those in control group,and the levels of interleukin-6(IL-6)and interleukin-4(IL-4)were lower than those in control group(P<0.05).After treatment,the levels of vascular endothelial growth factor(VEGF),fibroblast growth factor(bFGF),endothelial cell specific molecule-1(ESM-1),angiopoietin-2(Ang-2),B cell lymphoma-2(Bcl-2),survivin and Bcl-2 binding anti-apoptotic gene-1(Bag-1)in study group were lower than those in control group(P<0.05).Conclusion:Huachansu capsule combined with TP regimen can prevent the disease progression of patients with advanced ovarian cancer by inhibiting tumor angiogenesis,promoting tumor cell apoptosis and regulating immune function.