特发性间质性肺炎急性加重期患者血清TBIL、LDH、LTBP2检测的临床意义分析

Clinical Significance Analysisof Serum TBIL,LDH and LTBP2 Detection in Patients with Acute Exacerbation of Idiopathic Interstitial Pneumonia

目的:探讨特发性间质性肺炎急性加重期(AE-IIP)患者血清总胆红素(TBIL)、乳酸脱氢酶(LDH)、潜在转化生长因子β结合蛋白2(LTBP2)水平与预后的关系。方法:选取2018年1月~2023年8月我院收治的AE-IIP患者102例(AE-IIP组),根据随访3个月生存状态分为死亡组(30例)和存活组(72例),通过多因素Logistic回归分析AE-IIP患者死亡的因素。结果:与存活组比较,死亡组血清TBIL水平降低,LDH、LTBP2水平升高(P<0.05)。AE-IIP患者死亡的独立保护因素为一氧化碳弥散量(DLCO)、动脉血氧分压/吸氧分数(PaO_(2)/Fi O_(2))升高、TBIL升高,独立危险因素为LDH升高、LTBP2升高(P<0.05)。结论:AE-IIP患者血清TBIL水平降低和LDH、LTBP2水平升高,与不良预后密切相关。

Objective:To investigate the relationship between serum total bilirubin(TBIL),lactate dehydrogenase(LDH),latent transforming growth factor beta binding protein 2(LTBP2)levels and prognosis in patients with acute exacerbation of idiopathic interstitial pneumonia(AE-IIP).Methods:102 patients with AE-IIP(AE-IIP group)admitted to our hospital from January 2018 to August2023 were selected,patients were divided into death group(30 cases)and survival group(72 cases)according to the survival status after3 months of follow-up.The factors of death in patients with AE-IIP were analyzed by multivariate Logistic regression.Results:Compared with survival group,the serum TBIL level in death group was decreased,and the levels of LDH and LTBP2 were increased(P<0.05).The independent protective factors of death in patients with AE-IIP were increased dynamic diffusion lung capacity of carbon monoxide(DLCO),partial pressure of oxygen/fraction of inspired oxygen(PaO_(2)/Fi O_(2)),and TBIL,the independent risk factors were increased LDH and LTBP2(P<0.05).Conclusion:The decrease of serum TBIL level and the increase of LDH and LTBP2 levels in patients with AE-IIP are closely relate to the poor prognosis.