基于神经递质和肠道菌群探讨露甘露特钠胶囊联合盐酸多奈哌齐片治疗轻中度阿尔茨海默病的疗效

Exploring the Therapeutic Effect of Lumannate Sodium Capsules Combined with Donepezil Hydrochloride Tablets in the Treatment of Mild to Moderate Alzheimer's Disease Based on Neurotransmitters and Gut Microbiota

目的:探讨轻中度阿尔茨海默病(AD)患者采用盐酸多奈哌齐片、甘露特钠胶囊联合治疗后,患者神经递质、认知功能和肠道菌群的变化情况。方法:采用随机数字表法将我院2020年3月~2023年3月期间收治的102例AD患者分为对照组(n=51,盐酸多奈哌齐片治疗)和研究组(n=51,甘露特钠胶囊联合盐酸多奈哌齐片治疗)。对比两组患者相关量表评分、神经递质和肠道菌群的变化。结果:研究组治疗6个月后简易智能精神量表评分(MMSE)评分、日常生活能力量表(ADL)评分、血清乙酰胆碱(Ach)、5-羟色胺(5-HT)、谷氨酸(Glu)、粪便双歧杆菌、乳酸杆菌数量高于对照组,痴呆病理行为评定表(BEHAVE-AD)、粪便梭状芽胞杆菌、葡萄球菌、假单胞菌、变形杆菌数量低于对照组(P<0.05)。结论:轻中度AD患者采用盐酸多奈哌齐片、甘露特钠胶囊联合治疗,可改善认知功能,调节神经递质和肠道菌群。

Objective:To investigate the changes in neurotransmitters,cognitive function,and gut microbiota in patients with mild to moderate Alzheimer's disease(AD)treated with a combination of donepezil hydrochloride tablets and mannitol sodium capsules.Methods:The random number table method was used,102 AD patients admitted to our hospital from March 2020 to March 2023 were divided into control group(n=51,treated with donepezil hydrochloride tablets)and study group(n=51,treated with ganlute sodium capsules combine with donepezil hydrochloride tablets).The related scale scores,neurotransmitters and intestinal flora in two groups were compared.Results:The score of Mini-Mental State Examination(MMSE),Activity of Daily Living(ADL),serum acetylcholine(Ach),5-hydroxytryptamine(5-HT)and glutamic acid(Glu),number of fecal Bifidobacterium and Lactobacillus in study group was higher than that in control group 6 months after treatment,and the scores of Behavioral Pathology of Dementia(BEHAVE-AD),number of fecal Clostridium,Staphylococcus,Pseudomonas and Bacillus proteus in study group were lower than those in control group(P<0.05).Conclusion:Combination treatment of donepezil hydrochloride tablets and mannitol sodium capsules for mild to moderate AD patients,can improve cognitive function,regulate neurotransmitters and gut microbiota.