益气通腑汤联合乌司他丁对脓毒症胃肠功能障碍患者胃肠激素、肠道菌群和肠屏障标记物的影响

Effects of Yiqi Tongfu Decoction Combined with Ulinastatin on Gastrointestinal Hormones,Intestinal Flora and Intestinal Barrier Markers in Patients with Sepsis Gastrointestinal Dysfunction

目的:观察益气通腑汤联合乌司他丁对脓毒症胃肠功能障碍患者的影响。方法:按照随机数字表法将98例脓毒症胃肠功能障碍患者分为对照组(乌司他丁治疗)和治疗组(对照组的基础上加用益气通腑汤),各为49例。对比两组胃肠激素[胃动素(MOT)、胃泌素(GAS)]、肠道菌群[双歧杆菌、乳酸杆菌、肠杆菌、肠球菌、拟杆菌]和肠屏障标记物指标[二胺氧化酶(DAO)和D乳酸]情况。结果:治疗后与对照组相比,治疗组DAO、D乳酸、GAS水平、肠杆菌、肠球菌、拟杆菌菌落数下降,MOT水平、双歧杆菌、乳酸杆菌菌落数升高(P<0.05)。结论:益气通腑汤联合乌司他丁治疗可改善脓毒症胃肠功能障碍患者肠道菌群、胃肠激素和肠屏障标记物水平。

Objective:To observe the effects of yiqi tongfu decoction combined with ulinastatin on patients with sepsis gastrointestinal dysfunction.Methods:98 patients with sepsis gastrointestinal dysfunction were divided into control group(treated with ulinastatin)and treatment group(treated with yiqi tongfu decoction on the basis of control group)according to the random number table method,49 cases in each group.The gastrointestinal hormones[motilin(MOT),gastrin(GAS)],intestinal flora[Bifidobacterium,Lactobacillus,Enterobacter,Enterococcus,Bacteroides]and intestinal barrier markers[diamine oxidase(DAO)and D lactic acid]were compared between two groups.Results:After treatment,compared with control group,DAO,D lactic acid,GAS level,Enterobacter,Enterococcus,and Bacteroides colonies in treatment group decreased,while the MOT level,Bifidobacterium,and Lactobacillus colonies increased(P<0.05).Conclusion:Yiqi tongfu decoction combined with ulinastatin may improve the levels of intestinal flora,gastrointestinal hormones and intestinal barrier markers in patients with septic gastrointestinal dysfunction.