类风湿关节炎患者血清骨硬化蛋白、盐诱导激酶2与骨质疏松症的关系

Relationship between Serum Sclerostin,Salt-Induced Kinase 2 and Osteoporosis in Rheumatoid Arthritis Patients

目的:研究探讨类风湿关节炎患者血清骨硬化蛋白(SOST)、盐诱导激酶2(SIK2)与骨质疏松症的关系。方法:选取2020年9月~2023年9月本院收治的180例类风湿关节炎患者为对象,根据患者骨质疏松症发生情况将其分为骨质疏松组和非骨质疏松组,比较两组患者血清SOST、SIK2水平及其他临床资料,并采用Logistic多因素回归分析类风湿关节炎患者发生骨质疏松症的影响因素。结果:骨质疏松组年龄、类风湿关节炎病程、女性比例、使用糖皮质激素比例大于非骨质疏松组,血清SOST、SIK2均高于非骨质疏松组(P<0.05)。经Logistic多因素回归分析显示,高龄、类风湿关节炎病程长、SOST、SIK2升高是类风湿关节炎发生骨质疏松症的危险因素(P<0.05)。结论:血清SOST、SIK2在类风湿关节炎合并骨质疏松症患者中升高,且血清SOST、SIK2升高是类风湿关节炎患者发生骨质疏松症的危险因素。

Objective:To investigate the relationship between serum sclerostin(SOST),salt-induced kinase 2(SIK2)and osteoporosis in rheumatoid arthritis patients.Methods:A total of 180 rheumatoid arthritis patients admitted to our hospital from September 2020 to September 2023 were selected and divided into osteoporosis group and non-osteoporosis group according to the occurrence of osteoporosis.Serum SOST,SIK 2 levels and other clinical data were compared between the two groups,and Logistic multivariate regression was used to analyze the influencing factors of osteoporosis in patients with rheumatoid arthritis.Results:Age,rheumatoid arthritis duration,female proportion and glucocorticoid use in the osteoporosis group were greater than the non-osteoporosis group,and Serum SOST and SIK 2 were higher than the non-osteoporosis group(P<0.05).The advanced age,long duration of rheumatoid arthritis,elevated SOST and elevated SIK 2 were risk factors for rheumatoid arthritis with osteoporosis by Logistic multiple regression analysis(P<0.05).Conclusion:Serum SOST and SIK 2 were elevated in patients with rheumatoid arthritis complicated with osteoporosis,and elevated serum SOST and SIK 2 are the risk factors for osteoporosis in patients with rheumatoid arthritis.