血清ps-Tg、MMP-13及TgAb在分化型甲状腺癌患者手术前后变化及其与术后复发转移的相关性分析

Changes in Serum ps-Tg,MMP-13,and TgAb Levels before and after Surgery in Patients with Differentiated Thyroid Cancer and Their Correlation with Postoperative Recurrence and Metastasis

目的:探讨血清ps-Tg、MMP-13及TgAb在分化型甲状腺癌患者手术前后变化及其与术后复发转移的相关性分析。方法:选取我院2018.1到2021.1收治的100例分化型甲状腺癌患者,均采取根治性手术治疗,进行3年随访,记录血清水平变化。并记录术后复发转移发生率,分为复发转移组(n=25)及非复发转移组(n=75),对比血清水平,采用Spearman相关分析相关性,采用logistic回归分析预测价值。结果:术后3年ps-Tg、MMP-13及TgAb水平水平低于手术前(P<0.05),但术后1年与术后3年相比无差异(P>0.05);复发转移组与非复发转移组患者血清ps-Tg、MMP-13及TgAb的手术前、术后1年表达水平及下降百分比对比有差异,复发转移组高于非复发转移组(P<0.05);Spearman相关分析显示:ps-Tg、MMP-13及TgAb与分化型甲状腺癌术后复发转移呈正相关(P<0.05);logistics回归模型分析显示,ps-Tg、MMP-13及TgAb均为分独立影响因素(P<0.05)。结论:分化型甲状腺癌患者手术后1年期间血清ps-Tg、MMP-13及TgAb水平逐渐降低,术后1年到3年呈现平稳状态,且血清ps-Tg、MMP-13及TgAb与术后复发转移情况密切相关。

Objective:To explore the changes of serum ps-Tg,MMP-13,and TgAb in patients with differentiated thyroid carcinoma before and after surgery,and their correlation with postoperative recurrence and metastasis.Methods:100 differentiated thyroid cancer patients admitted from 2018.1 to 2021.1 in our hospital were treated with radical surgery for 3-year follow-up to record the changes in serum level.The incidence of postoperative recurrence and metastasis was recorded and divided into recurrence group(n=25)and non-recurrence group(n=75).Comparing serum levels,Spearman correlation analysis and predicted value was used for logistic regression analysis.Result:The levels of ps-Tg,MMP-13 and TgAb were lower than before surgery(P<0.05),However,there was no difference in 1 year compared with 3 years after surgery(P>0.05);The expression level and percentage decrease of serum ps-Tg,MMP-13 and TgAb between 1-year patients of recurrence and non-recurrence patients,The group with recurrent metastasis was higher than the non-recurrent metastasis group(P<0.05);Spearman Correlation analysis showed that ps-Tg,MMP-13 and TgAb were positively correlated with the recurrence and metastasis of differentiated thyroid carcinoma after surgery(P<0.05);logistics From the regression model analysis,The ps-Tg,MMP-13 and TgAb were all classified as independent influencing factors(P<0.05).Conclusion:The serum levels of ps-Tg,MMP-13,and TgAb gradually decrease in patients with differentiated thyroid cancer after surgery for 1 year,and show a stable state from 1 to 3 years after surgery.The serum levels of ps-Tg,MMP-13,and TgAb are closely related to the postoperative recurrence and metastasis.