血清可溶性CD276、生长分化因子15联合胸苷激酶对高、低级别浆液性卵巢癌的鉴别诊断及预后价值分析

Differential Diagnosis and Prognostic Value Analysis of Serum Soluble CD276,Growth Differentiation Factor 15 Combined with Thymidine Kinase in High-grade and Low-grade Serous Ovarian Cancer

目的:探讨血清sCD276、CDF15联合TK1对高、低级别浆液性卵巢癌的鉴别诊断及预后价值。方法:选取我院2019.1到2021.1收治的60例浆液性卵巢癌患者,分为高级别组(n=32)与低级别组(n=28),另选取同期收治的30例良性卵巢肿瘤患者作为对照组,比较三组相关指标;随访3年,分为预后不良组(n=20)和预后良好组(n=40),对比两组相关指标,并探讨预后预测价值。结果:高级别组患者sCD276、CDF15、TK1高于其他两组(P<0.05);ROC曲线显示三者联合诊断的灵敏度和特异度均高于单一诊断;预后分析中,FIGO分期、淋巴结转移、远处转移、肿瘤分化程度、sCD276、CDF15、TK1表达水平在两组之间存在差异(P<0.05);logistic回归分析表明:FIGO分期、远处转移及sCD276、CDF15、TK1为高、低级别浆液性卵巢癌预后独立影响因素(P<0.05)。结论:sCD276、CDF15、TK1对浆液性卵巢癌的高、低级别鉴定具有重要意义,且三者联合诊断灵敏度、特异度较高,可进一步预测浆液性卵巢癌的预后水平。

Objective:To investigate the differential diagnosis and prognostic value of serum sCD276,CDF15 and TK1 in high and low grade serous ovarian cancer.Methods:60 patients with serous ovarian cancer admitted to our hospital from January 2019 to January 2019 were divided into high-grade group(n=32)and low-grade group(n=28),and 30 patients with benign ovarian tumor admitted during the same period were selected as control group.The patients were followed up for 3 years and divided into poor prognosis group(n=20)and good prognosis group(n=40).The correlation indexes of the two groups were compared and the prognostic value was discussed.Results:sCD276,CDF15 and TK1 in high-grade group were higher than those in other two groups(P<0.05);ROC curve showed that the sensitivity and specificity of combined diagnosis were higher than that of single diagnosis.In prognosis analysis,FIGO stage,lymph node metastasis,distant metastasis,tumor differentiation,sCD276,CDF15 and TK1 expression levels were different between the two groups(P<0.05).logistic regression analysis showed that FIGO stage,distant metastasis,sCD276,CDF15 and TK1 were independent prognostic factors of high and low grade serous ovarian cancer(P<0.05).Conclusion:sCD276,CDF15 and TK1 are of great significance in the identification of high and low grade serous ovarian cancer,and the combined diagnosis of SCD276,CDF15 and TK1has high sensitivity and specificity,which can further predict the prognosis of serous ovarian cancer.