乳腺浸润性小叶癌组织FOXP1、FOXR2的表达与临床病理特征和预后的关系研究

Study on the Relationship between the FOXP1 and FOXR2 Expression in Breast Invasive Lobular Carcinoma Tissues and Clinicopathological Features and Prognosis

目的:探讨乳腺浸润性小叶癌(ILC)组织叉头框蛋白P1(FOXP1)、FOXR2的表达与临床病理特征和预后的关系。方法:选取248例乳腺ILC患者,分析乳腺ILC组织FOXP1、FOXR2表达与临床病理特征的关系。根据乳腺ILC组织中FOXP1、FOXR2表达,将乳腺ILC患者分为阳性/阴性表达组,采用Kaplan-Meier法绘制各组生存曲线,采用多因素Cox回归分析影响乳腺ILC患者预后的因素。结果:与癌旁组织比较,乳腺ILC组织FOXP1阳性表达率降低,FOXR2阳性表达率升高(P<0.05)。乳腺ILC组织FOXP1、FOXR2表达与分化程度、TNM分期、淋巴结转移有关(P<0.05)。随访3年,248例乳腺ILC患者总生存率为69.11%。FOXP1阳性表达组总生存率高于阴性表达组,FOXR2阳性表达组总生存率低于阴性表达组(P<0.05)。乳腺ILC患者死亡的独立危险因素包括TNM分期Ⅲ~Ⅳ期、三阴性和FOXR2阳性,独立保护因素则为FOXP1阳性(P<0.05)。结论:乳腺ILC组织FOXP1阳性表达降低,FOXR2阳性表达升高,其异常表达与患者分化程度、TNM分期等恶性病理特征及预后不良有关。

Objective:To investigate the relationship between the forkhead box protein P1(FOXP1)and FOXR2 expression in breast invasive lobular carcinoma(ILC)tissues and clinicopathological features and prognosis.Methods:248 breast ILC patients were selected,and the relationship between FOXP1 and FOXR2 expression in breast ILC tissues and clinicopathological features were analyzed.According to the FOXP1 and FOXR2 expression in breast ILC tissues,breast ILC patients were divided into positive/negative expression groups,survival curves of each group were drawn using the Kaplan-Meier method,the factors affecting the prognosis of breast ILC patients was analyzed by multivariate Cox regression analysis.Results:Compared with adjacent tissues,the FOXP1 positive expression rate in breast ILC tissues was decreased,and the FOXR2 positive expression rate was increased(P<0.05).The FOXP1 and FOXR2 expression in breast ILC tissues were related to the differentiation degree,TNM stage and lymph node metastasis(P<0.05).3years after follow-up,the overall survival rate of 248 breast ILC patients was 69.11%.The overall survival rate in FOXP1 positive expression group was higher than that in negative expression group,and the overall survival rate in FOXR2 positive expression group was lower than that in negative expression group(P<0.05).The independent risk factors for death in breast ILC patients included TNM stage III~IV,triple negative and FOXR2 positive,and the independent protective factor was FOXP1 positive(P<0.05).Conclusions:The FOXP1 positive expression in breast ILC tissues is decreased,and the FOXR2 positive expression is increased,its abnormal expression is related to the differentiation degree,TNM stage and other malignant pathological features and poor prognosis.