FS-LASIK围术期应用0.05%环孢素滴眼液(Ⅱ)对术后干眼症状及泪膜稳定性的影响

Effect of 0.05%Cyclosporine Eye Drops(Ⅱ)on Dry Eye Symptoms and Tear Film Stability after FS-LASIK

目的:观察飞秒激光辅助准分子激光原位角膜磨镶术(FS-LASIK)围术期应用0.05%环孢素(Cs A)滴眼液(Ⅱ)对术后干眼症状及泪膜稳定性的影响。方法:92例行FS-LASIK手术且术后出现干眼症状的患者分为术前使用0.05%CsA滴眼液(Ⅱ)组(A组)36例、术后1周开始使用0.05%CsA滴眼液(Ⅱ)组(B组)32例、不使用0.05%CsA滴眼液(Ⅱ)组(C组)24例。对比三组中国干眼问卷评分、泪膜破裂时间(BUT)、角膜荧光素染色(FL)、结膜丽丝胺绿染色(LG)、泪液分泌试验(SIt)。结果:B组、C组术后1周、1个月及3个月中国干眼问卷评分、FL、LG高于A组,且C组高于B组(P<0.05)。B组、C组术后1周、1个月及3个月BUT、SIt低于A组,且C组低于B组(P<0.05)。结论:FS-LASIK术前使用0.05%CsA滴眼液(Ⅱ)可以有效缓解患者术后干眼症状,提高泪膜稳定性。

Objective:To observe the effect of perioperative application of 0.05%cyclosporine(CsA)eye drops(II)on dry eye symptoms and tear film stability after femtosecond laser-assisted laser in situ keratomileusis(FS-LASIK).Methods:92 patients who underwent FS-LASIK surgery and had dry eye symptoms after surgery were divided into 36 patients who used 0.05%CsA eye drops before operation(group A),32 patients who used 0.05%CsA eye drops 1 week after operation(group B),and 24 patients who did not use 0.05%CsA eye drops(group C).The Chinese dry eye questionnaire score,tear film rupture time(BUT),corneal fluorescein staining(FL),conjunctival lissamine green staining(LG),and tear secretion test(SIt)were compared among three groups.Results:The Chinese dry eye questionnaire score,FL and LG in group B and group C were higher than those in group A at 1 week,1 month and 3 months after operation,and those in group C were higher than those in group B(P<0.05).BUT and SIt in group B and group C were lower than those in group A at 1 week,1 month and 3 months after operation,and those in group C were lower than those in group B(P<0.05).Conclusion:The use of 0.05%CsA eye drops(II)before FS-LASIK can effectively alleviate the symptoms of dry eye,and improve the stability of tear film.