舒眠胶囊联合阿戈美拉汀片对抑郁症伴失眠患者多导睡眠图特征和血清5-HT、BDNF、GDNF的影响

Effects of Shumian Capsules Combined with Agomelatine Tablets on Polysomnography Characteristics and Serum 5-HT,BDNF and GDNF in Patients with Depression and Insomnia

目的:探讨舒眠胶囊联合阿戈美拉汀片对抑郁症伴失眠患者多导睡眠图特征和血清5-羟色胺(5-HT)、胶质细胞源性神经营养因子(GDNF)、脑源性神经营养因子(BDNF)的影响。方法:采用随机数字表法将94例抑郁症伴失眠患者分为研究组(接受阿戈美拉汀片、舒眠胶囊联合治疗)、对照组(接受阿戈美拉汀片治疗),各为47例。对比两组汉密顿抑郁量表-17(HAMD-17)、匹兹堡睡眠质量指数(PSQI)、疲劳量表(FS-14)量表评分、5-HT、BDNF、GDNF、多导睡眠监测(PSG)相关指标[总睡眠时间(TST)、睡眠效率(SE)、非快速眼动睡眠1、2、3期(NREM1、NREM2、NREM3)]。结果:与对照组治疗后相比,研究组HAMD-17、PSQI、FS-14评分相对更低(P<0.05)。与对照组治疗后相比,研究组5-HT、BDNF、GDNF相对更高(P<0.05)。与对照组治疗后相比,研究组TST、SE、NREM1、NREM2、NREM3相对更高(P<0.05)。结论:抑郁症伴失眠患者经阿戈美拉汀片和舒眠胶囊联合治疗,失眠和抑郁症状得到显著改善,可能与改善血清5-HT、BDNF、GDNF水平有关。

Objective:To investigate the effects of shumian capsules combined with agomelatine tablets on polysomnography characteristics and serum 5-hydroxytryptamine(5-HT),glial cell line-derived neurotrophic factor(GDNF)and brain-derived neurotrophic factor(BDNF)in patients with depression and insomnia.Methods:94 patients with depression and insomnia who were divided into study group(treated with agomelatine tablets and shumian capsules)and control group(treated with agomelatine tablets)according to the random number table method,47 cases in each group.The Hamilton Depression Scale-17(HAMD-17),Pittsburgh Sleep Quality Index(PSQI),Fatigue Scale(FS-14)scale score,5-HT,BDNF,GDNF,polysomnography(PSG)related indicators[total sleep time(TST),sleep efficiency(SE),non-rapid eye movement sleep 1,2,3(NREM1,NREM2,NREM3)]were compared between two groups.Results:Compared with control group after treatment,the scores of HAMD-17,PSQI and FS-14 in study group were relatively lower(P<0.05).Compared with control group after treatment,5-HT,BDNF and GDNF in study group were relatively higher(P<0.05).Compared with control group after treatment,TST,SE,NREM1,NREM2 and NREM3 in study group were relatively higher(P<0.05).Conclusion:Patients with depression and insomnia are treat with agomelatine tablets and shumian capsules,the symptoms of insomnia and depression are significantly improve,which may be relate to the improvement of serum 5-HT,BDNF and GDNF levels.