精源性卵母细胞激活因子缺乏导致ICSI受精失败的研究进展

Advances in genetic factors of ICSI fertilization failure due to the deficiency of sperm-borne oocyte activation factor

受精是一个复杂的生物学过程,其中任意一个环节出现异常都会导致受精问题的出现。虽然卵胞质内单精子注射(intracytoplasmic sperm injection,ICSI)技术的出现极大改善了男性精子因素引起的不孕问题,但临床医生仍会遇到一些不明原因的ICSI受精失败问题。随着基因检测技术的迅猛发展,临床科研人员已先后在此类ICSI受精失败患者人群中发现了导致精源性卵母细胞激活因子(sperm-borne oocyte activation factor,SOAF)减少的致病基因PLCZ1、ACTL7A、ACTL9及IQCN,但目前尚缺乏对此类受精失败的系统总结。本文将结合近期的相关报道,对SOAF缺乏导致ICSI受精失败的遗传因素及治疗方法作系统综述。

Fertilization is a complex biological process,in which any abnormality will lead to the occurrence of fertilization failure.Although the emergence of intracytoplasmic sperm injection(ICSI)technology has greatly improved infertility caused by male sperm factors,clinicians still encounter the problem of some unexplained ICSI fertilization failure.With the development of genetic testing technology,clinical researchers have identified pathogenic gene mutations such as PLCZ1,ACTL7A,ACTL9,IQCN in patients associated with the deficiency of sperm-borne oocyte activation factor(SOAF).However,there is currently a lack of a systematic summary of such fertilization failure.Here,we will provide a systematic review of genetic factors and treatment methods of SOAF deficiency leading to ICSI fertilization failure.