钠-葡萄糖协同转运蛋白2抑制剂在肥胖相关性肾病中的作用及机制

Effects and mechanisms of SGLT2 inhibitors in obesity-related glomerulopathy

随着全球肥胖患病率的上升,与肥胖相关的多种疾病,特别是肾脏疾病的发病率也在上升。肥胖是慢性肾脏疾病的独立危险因素,肥胖相关性肾病的病理生理机制复杂,涉及肾小球血流动力改变、肾素-血管紧张素-醛固酮系统过度激活、胰岛素抵抗、炎症反应及氧化应激等。钠-葡萄糖协同转运蛋白2抑制剂作为一种新型降血糖药物,已经被证实具有显著的肾脏获益。该文综述了肥胖相关性肾病的发病机制及钠-葡萄糖协同转运蛋白2抑制剂对其保护作用及机制。

With increase of the global obesity prevalence,the incidence of many diseases associated with obesity,especially kidney disease,is also on the rise.Obesity itself is an independent risk factor for chronic kidney disease.The pathophysiology of obesity-related glomerulopathy is complex and involves changes in glomerular blood flow dynamics,excessive activation of the renin-angiotensin-aldosterone system,insulin resistance,inflammation,oxidative stress and so on.SGLT-2 inhibitors,as a novel class of antidiabetic drugs,have been proven to have significant renal benefits.This article reviews the pathogenic mechanisms of obesity-related glomerulopathy and the protective effects and mechanisms of SGLT-2 inhibitors on it.