PKM2在牙源性角化囊肿中的研究进展

Research Progress of PKM2 in Odontogenic Keratocysts

牙源性角化囊肿(odontogenic keratocyst, OKC)是一种具有潜在侵袭性、易复发和多发的发育性囊肿,能量代谢途径主要以糖酵解为主。丙酮酸激酶的M2亚型(pyruvate kinase M2,PKM2)是糖酵解关键调动因子,在调控肿瘤代谢微环境中发挥重要作用。为了降低OKC术后复发率,同时合理保存和重建患者口腔结构和功能,OKC相关基础和临床研究不断深入,特别是中医药对口腔肿瘤免疫微环境稳态作用机理值得深入研究。本文针对PKM2在OKC中的研究进展作一综述,以期为OKC的临床治疗提供参考及新思路。

The odontogenic keratocyst(OKC)is a developmental cyst that has high potential for invasiveness,easy recurrence,and multiple occurrences.Its energy metabolism pathway is mainly glycolysis.Pyruvate kinase M2(PKM2)is a key driving factor of glycolysis and plays an important role in regulating the tumor metabolic microenvironment.The traditional Chinese medicine(TCM)has a long history of treating tumors with its unique theory of"steady-state"effect on the tumor immune microenvironment.This review will delve into the regulation of PKM2 in respect of odontogenic keratocysts,aiming to provide new ideas for the clinical treatment of OKC with traditional Chinese medicine.