司库奇尤单抗诱发口腔念珠菌病1例

Oral Candidiasis Induced by Secukinumab:A Case Report

口腔念珠菌病是一种常见的口腔黏膜真菌感染性疾病,多见于各类因素导致机体防御能力降低的人群。由于广谱抗生素、糖皮质激素的广泛应用,以及近年来一些新型免疫调节制剂和生物制剂的不断问世,由药物导致的医源性口腔念珠菌病逐年增多。在口腔念珠菌病的诊疗过程中,控制诱发因素是取得良好疗效的关键,因此明确该病的诱发因素对于规范诊疗具有重要意义。本文报道1例因治疗银屑病使用司库奇尤单抗诱发口腔念珠菌病的诊疗过程,以期为临床认识口腔念珠菌病新的诱发因素及制定相应诊疗策略提供参考。

Oral candidiasis is a common fungal infectious disease of the oral mucosa,which is more often seen in people with reduced defenses due to various factors.With the wide application of broad-spectrum antibiotics,glucocorticoids,and the development of novel immunomodulatory agents and biologics,iatrogenic oral candidiasis caused by medicine usage is increasing recently.In the diagnosis and treatment of oral candidiasis,controlling the predisposing factors is the key to achieving good therapeutic effect,so it is important to clarify the predisposing factors of the disease for the standardized diagnosis and treatment.Here we reports a case of oral candidiasis induced by the use of secukinumab for the treatment of psoriasis,aiming to provide reference for clinical understanding of new causes of oral candidiasis and formulating corresponding treatment strategies.