Sirt1因子在糖尿病性白内障发病机制中的研究进展

Research progress of Sirt1 factor in the pathogenesis of diabetic cataract

Sirtuin(SIRT)家族的成员是Ⅲ类组蛋白去乙酰化酶(HDACⅢ),与酵母沉默信息调节因子2(Sir2)同源,Sirtuins可以NAD~+依赖的方式介导组蛋白和非组蛋白的脱乙酰化。糖尿病性白内障(DC)是糖尿病最重要的并发症之一,能够导致视力障碍和失明。随着Sirt1信号通路的深入研究,发现该信号通路在DC的发生发展中具有重要的作用,文章从Sirt1对DC不同发病机制的影响对sirt1在DC中的研究进展进行综述。

Members of the Sirtuin(SIRT)family are class III histone deacetylases(HDACⅢ)homologous to yeast silencing information regulator 2(Sir2),which mediates histone and non-histone deacetylation in a NAD+-dependent manner.Diabetic cataract(DC)is one of the most important complications of diabetes,which can lead to visual impairment and blindness.With the in-depth study of the Sirt1 signaling pathway,it is found that this signaling pathway plays an important role in the occurrence and development of DC,and this article reviews the research progress of Sirt1 in DC by examining its impact on different pathogenesis.