N-Bromosuccinimide-Promoted Direct Phosphorylation of Alcohols with P(O)-H Compounds

N-溴代丁二酰亚胺促进的P(O)-H化合物参与的醇的直接磷酸化反应

A mild,green,convenient and scalable N-bromosuccinimide(NBS)promoted direct phosphorylation strategy of secondary phosphine oxides and alcohols for the synthesis of various phosphinate esters was developed.A variety of substrates are well-tolerated and the desirable compounds were afforded in moderate to excellent yields(up to 92%).This reaction is conducted at room temperature without the addition of any oxidant and metal catalyst,which provides a new strategy for the synthesis of phosphinate esters.

发展了一种温和、绿色、便捷和可扩大的N-溴代丁二酰亚胺(NBS)促进的次级膦氧化合物与醇的直接磷酸化策略,用于合成多种次磷酸酯.底物适用范围广泛且耐受性好,能以中等至优异的收率(高达92%)合成目标化合物.该反应在室温下进行,无需添加任何氧化剂和金属催化剂,为次磷酸酯衍生物的合成提供了一种新的策略.