短肽类肠内营养剂在白血病患儿营养支持中的应用效果

Application effect of short peptide enteral nutrition in nutritional support for children with leukemia

目的观察短肽类肠内营养剂在白血病患儿中的营养支持效果。方法选取2022年6月至2023年6月曲靖市妇幼保健院收治的60例白血病患儿为研究对象,按照随机数字表法分为对照组和观察组,每组各30例。对照组接受日常经口饮食,观察组额外使用短肽类肠内营养剂。比较两组患儿的营养状态和临床指标变化。结果干预后,观察组的血清白蛋白和前白蛋白高于对照组,差异有统计学意义(P<0.05)。治疗期间两组不良反应发生情况比较,差异无统计学意义(P>0.05)。干预后,观察组的天门冬氨酸氨基转移酶、丙氨酸氨基转移酶、血清肌酐及血清尿素氮水平均低于对照组,差异有统计学意义(P<0.05)。干预后,观察组的血浆活化部分凝血活酶时间短于对照组,血小板计数高于对照组,差异有统计学意义(P<0.05)。干预后,观察组CD4+和CD4+/CD8+均高于对照组,差异有统计学意义(P<0.05)。结论短肽类肠内营养制剂用于白血病化疗患儿能有效改善患儿营养状况和凝血功能,减轻对肝肾功能的损伤。

Objective To observe the nutritional support effect of short peptide enteral nutrition in children with leukemia.Methods Sixty children with leukemia treated in Qujing Maternal and Child Health Hospital from June 2022 to June 2023 were selected as the study objects,and were divided into control group and observation group according to random number table method,with 30 cases in each group.The control group received daily oral diet,while the observation group received additional short peptide enteral nutrition.The nutritional status and clinical indicators of two groups of children were compared.Results After intervention,the albumin and pre-albumin in the observation group were significantly higher than those in the control group,the differences were statistically significant(P<0.05).There was no statistical significance in the occurrence of adverse reactions between the two groups during treatment(P>0.05).After intervention,the aspartate aminotransferase,alanine aminotransferase,serum creatinine,and blood urea nitrogen in the observation group were lower than those in the control group,the differences were statistically significant(P<0.05).After intervention,the plasma activated partial thromboplastin time in observation group was shorter than that in control group,and the platelet count was higher than that in control group,the differences were statistically significant(P<0.05).After intervention,CD4+and CD4+/CD8+in observation group were higher than those in control group,the difference were statistically significant(P<0.05).Conclusion The short peptide enteral nutrition preparations were used in children with leukemia undergoing chemotherapy can effectively improve their nutritional status and coagulation function,and reduce damage to liver and kidney function.