输尿管支架置入术对妊娠合并输尿管结石患者炎性因子及妊娠结局的影响

Effects of the ureteral stenting inserted for treating women with ureteral calculus during pregnancy on their microinflammation and pregnancy outcomes

目的:回顾性分析输尿管支架置入术对妊娠合并输尿管结石患者炎性因子及妊娠结局的影响。方法:选取本院2020年12月-2023年12月住院的妊娠合并输尿管结石患者94例临床资料,根据治疗方式分组,分为采取保守治疗(保守组)或采取输尿管支架置入术(支架组)治疗,比较两组临床疗效、治疗前后炎症细胞因子水平及疼痛程度、不良妊娠结局发生率。结果:治疗有效率支架组(89.6%)高于保守组(65.2%);治疗24h后,支架组血清降钙素原(0.06±0.03 ng/ml)、C-反应蛋白(5.13±1.28 ng/L)和白细胞(6.25±1.26)×10^(9)/L水平均低于保守组(0.08±0.05 ng/ml、8.12±2.35 ng/L、8.36×10^(9)/L±1.82×10^(9)/L),疼痛视觉模拟评分(2.14±0.42分)低于保守组(3.23±0.63分),不良妊娠结局发生率(2.1%)低于保守组(17.4%)(均P<0.05)。结论:输尿管支架置入术治疗妊娠合并输尿管结石有较好疗效,可有效缓解患者炎症反应,解除梗阻保护肾功能,促进康复,同时具备较好的安全性。

Objective:To investigate the effects of the ureteral stenting inserted for treating pregnant women with ureteral calculus during pregnancy on their microinflammation and pregnancy outcomes.Methods:The clinical data of 94 women with ureteral calculus during pregnancy who had hospitalized from December 2020 to December 2023 were selected.These women were divided into two groups according to the different treatment.The women in the study group had received ureteral stenting,while the women in the control group had received conservative treatment.The clinical efficacy,the inflammatory cytokines level before and after treatment,the pain degree and the incidence of the adverse pregnancy outcomes of the women were compared between two groups.Results:The effective rate(89.6%)of the women in the study group was significantly higher than that(65.2%)of the women in the control group.After 24 hours of treatment,the levels of the serum procalcitonin(0.06±0.03ng/ml)and C-reactive protein(5.13±1.28ng/L),and the white blood cell count(6.25±1.26×10^(9)/L)of the women in the study group were significantly lower than those(0.08±0.05ng/ml,8.12±2.35ng/L)and(8.36±1.82×10^(9)/L)of the women in the control group.The visual analogue scale of the pain degree(2.14±0.42 points)and the incidence of the adverse pregnancy outcomes(2.1%)of the women in the study group were significantly lower than those(3.23±0.63 points and 17.4%)of the women in the control group(all P<0.05).Conclusion:The application of the ureteral stenting for treating the pregnant women with ureteral calculus during pregnancy has better effectiveness,and which can effectively attenuate the inflammation response,protect the renal function by relieving the obstruction and promote the recovery of the women,and with the better safety.