HDP孕妇血清IL-12、ANGPTL2、sICAM-1表达及预测不良妊娠结局价值

Expressions of the serum interleukin-12,angiopoietin-like protein 2 and soluble cell adhesion factor-1 of women with hypertensive disorder of pregnancy(HDP)and their values for predicting the adverse pregnancy outcomes

目的:分析妊娠期高血压疾病(HDP)孕妇血清白介素-12(IL-12)、血管生成素样蛋白2(ANGPTL2)、可溶性细胞黏附因子(sICAM-1)及其对HDP患者不良妊娠结局的预测价值。方法:选取2020年5月-2023年5月本院收治的HDP孕妇112例临床资料纳入HDP组,同期114例非HDP孕妇作为对照组,根据妊娠结局将HDP组分为不良组(n=39)与良好组(n=73),比较各组血清IL-12、ANGPTL2、sICAM-1水平。采用受试者工作特征(ROC)曲线分析血清IL-12,ANGPTL2、sICAM-1水平对HDP孕妇不良妊娠结局的预测价值。结果:HDP组血清IL-12(40.48±9.10 pg/ml)、ANGPTL2(8.54±2.21 ng/ml)、sICAM-1(285.58±41.21 ng/ml)水平均高于与对照组(17.90±7.33 pg/ml、6.46±1.25 ng/ml、134.11±23.21 ng/ml),且HDP组妊娠结局不良组血清IL-12、ANGPTL2、sICAM-1水平高于良好组(均P<0.05)。血清IL-12、ANGPTL2、sICAM-1联合预测HDP患者不良结局的ROC曲线下面积为0.858,特异度(81.7%)、灵敏度(90.4%)均高于单独指标预测。结论:HDP患者血清IL-12、ANGPTL2、sICAM-1表达上调且不良妊娠结局者水平更高,可作为预测HDP患者不良结局的指标。

Objective:To analyze the serum interleukin-12(IL-12),angiopoietin-like protein 2(ANGPTL2)and soluble cell adhesion factor-1(sICAM-1)of pregnant women with hypertensive disorder of pregnancy(HDP),and to study the values of the levels of the serum IL-12,ANGPTL2 and sICAM-1 of the women for predicting their adverse pregnancy outcomes.Methods:The clinical data of 112pregnant women with HDP from May 2020 to May 2023 were selected in study group retrospectively.114 pregnant women without HDP were selected in control group during the same period.The women in the study group were divided in to group A(39cases with adverse pregnancy outcomes)and group B(73cases with normal pregnancy outcomes)according to the pregnancy outcomes of the women.The levels of the serum IL-12,ANGPTL2,and sICAM-1of the women were compared among these groups.The values of the levels of serum IL-12,ANGPTL2 and sICAM-1 of the women for predicting their adverse pregnancy outcomes were evaluated by receiver operating characteristic(ROC)curve.Results:The levels of serum IL-12(40.48±9.10pg/ml),ANGPTL2(8.54±2.21ng/ml)and sICAM-1(285.58±41.21ng/ml)of the women in the study group were significantly higher than those(17.90±7.33pg/ml,6.46±1.25ng/ml and 134.11±23.21ng/ml)of the women in the control group.The levels of serum IL-12,ANGPTL2 and sICAM-1 of the women in group A were significantly higher than those of the women in group B(all P<0.05).The area under the ROC curve,the specificity and the sensitivity of the combined serum IL-12,ANGPTL2 and sICAM-1 levels of the women with HDP for predicting their adverse pregnancy outcomes were 0.858,81.7%and 90.4%,respectively,and which were significantly higher than that of the IL-12 level,the ANGPTL2 level or the sICAM-1 level alone.Conclusion:The levels of the serum IL-12,ANGPTL2 and sICAM-1 of the women with HDP are up-regulation,and which of the women with HDP and with the adverse pregnancy outcomes increase higher,so the serum IL-12 level,ANGPTL2 and sICAM-1 of the women with HDP can be used as the predictors of their adverse pregnancy outcomes.