GDM患者血清25(OH)D水平及与CRP、PTX3、SAP的相关性

Correlation between the serum25-hydroxyvitamin D level of women with gestational diabetes mellitus and their levels of C-reactive protein,pentamer protein 3 and amyloid P

目的:探讨妊娠期糖尿病(GDM)患者血清25-羟基维生素D[25(OH)D]水平及与C反应蛋白(CRP)、正五聚体蛋白3(PTX3)、淀粉样蛋白P(SAP)的相关性。方法:纳入2022年1月-2023年6月本院收治的孕中期(24~28周)GDM患者100例(GDM组),并按1:1比例选取同期体检健康孕妇100例纳入对照组,跟踪随访至孕晚期(31~38周),观察两组孕中期及孕晚期血清25(OH)D、CRP、PTX3、SAP及糖代谢指标变化,通过Pearson相关性分析各指标间相关性。结果:GDM组孕中期及孕晚期血清25(OH)D水平(21.75±8.20 mmol/L、20.88±4.36 mmol/L)均低于对照组(24.25±8.84 mmol/L、22.75±8.21 mmol/L),超敏C反应蛋白(Hs-CRP)、SAP、PTX3及肿瘤坏死因子α(TNF-α)、白介素-6(IL-6)水平均高于对照组,空腹血糖(FPG)、空腹胰岛素(FINS)、胰岛素抵抗指数(HOMA-IR)水平均高于对照组(均P<0.05)。Pearson相关性分析,GDM组孕中期及孕晚期血清25(OH)D与Hs-CRP、PTX3、FPG、FINS、HOMA-IR、IL-6均呈负相关关系(P<0.05),与SAP、TNF-α无相关性(P>0.05);Hs-CRP、TNF-α、PTX3、IL-6均与FPG、FINS、HOMA-IR呈正相关关系(均P<0.05),SAP与FPG、FINS、HOMA-IR无相关性(P>0.05)。结论:GDM患者血清25(OH)D表达水平较低,且其水平与Hs-CRP、PTX3、IL-6呈负相关,与胰岛素抵抗存在正相关性,但与SAP无明显相关性。

Objective:To investigate the correlation between the serum 25-hydroxyvitamin D level of pregnant women with gestational diabetes mellitus(GDM)and their levels of C-reactive protein(CRP),pentamer protein 3(PTX3)and amyloid P(SAP).Methods:100 pregnant women with GDM during the second trimester of pregnancy(24-28gestational weeks)were included in observation group,and 100healthy pregnant women were selected in control group from January 2022 to June 2023.The women in the two groups were followed up to the third trimester of pregnancy(31-38 gestational weeks).The changes of the levels of the serum 25(OH)D,CRP,PTX3,SAP and the glucose metabolism indexes of the women in the two groups during the second and the third trimester of pregnancy were observed.Pearson correlation was used to analyze the correlation among the levels of the serum 25(OH)D,CRP,PTX3,SAP and the glucose metabolism indexes of the women.Results:The serum 25(OH)D levels in the second and in third trimester of pregnancy(21.75±8.20mmol/L and 20.88±4.36mmol/L)of the women in the observation group were significantly lower than those(24.25±8.84mmol/L and 22.75±8.21mmol/L)of the women in the control group.The levels of high-sensitivity C-reactive protein(Hs-CRP),SAP,PTX3,tumor necrosis factor-α(TNF-α)and interleukin-6(IL-6)of the women in the observation group were significantly higher than those of the women in the control group.The levels of the fasting plasma glucose(FPG),fasting insulin(FINS),and the value of the insulin resistance index of homeostasis model assessment of insulin resistance(HOMA-IR)of the women in the observation group were significantly higher than those of the women in the control group(all P<0.05).Pearson correlation analysis showed that the serum 25(OH)D levels of the women in the observation group during the second and the third trimester of pregnancy were negatively correlated with their Hs-CRP,PTX3,FPG,FINS,HOMA-IR and IL-6levels(P<0.05),but which were not correlated with their SAP and TNF-α levels(P>0.05).The levels of the Hs-CRP,TNF-α,PTX3 and IL-6of the women in the observation group during the second and the third trimester of pregnancy were positively correlated with their FPG and FINS levels,and their HOMA-IR value(all P<0.05),while the SAP level of the women was not correlated with their FPG and FINS levels,and their HOMA-IR value(P>0.05).Conclusion:The level of serum 25(OH)D of the pregnant women with GDM is low,and which is negatively correlated with the levels of Hs-CRP,PTX3 and IL-6 of the women,and was positively correlated with the insulin resistance of the women,and which has no significant correlation with the SAP level of the women.