HDP患者血清尿酸水平及与PE的发生关系

Correlation between the serum uric acid level of women with hypertensive disorders complicating pregnancy and their preeclampsia occurrence

目的:探讨妊娠期高血压疾病(HDP)患者血清尿酸水平及与发生子痫前期(PE)关系。方法:选择2017年2月-2022年6月本院诊治的HDP孕妇500例临床资料,以血清尿酸水平分组,血清尿酸≥360μmol/L为高尿酸组(n=312),<360μmol/L为非高尿酸组(n=188),统计两组高血压分级情况,Pearson相关性分析血清尿酸与收缩压和舒张压的相关性;采取多因素logistic回归分析HDP患者发生PE的危险因素。结果:高尿酸组HDP分级高于非高尿酸组,HDP孕妇血清尿酸水平与其收缩压和舒张压均呈正相关,500例随访最终有105例(21.0%)发展为PE,PE患者血清尿酸≥360μmol/L占比(81.0%)高于非PE患者(38.0%)(均P<0.05)。多因素回归分析,血清尿酸≥360μmol/L,年龄≥35岁、孕前体质指数≥28kg/m^(2)、有PE家族史、有既往PE史均是HDP并发PE的独立危险因素(均P<0.05)。结论:HDP患者血清尿酸水平与HDP严重程度呈正相关,且是其发生PE的独立危险因素。

Objective:To investigate the correlation between the serum uric acid level of pregnant women with hypertensive disorders complicating pregnancy(HDP)and their preeclampsia occurrence.Methods:The clinical data of 500 pregnant women with HDP who had diagnosed and treated in the hospital from February 2017 to June 2022 were selected in this study.These women were divided into group A(312 women with the serum uric acid level≥360μmol/L)and group B(188 women with the serum uric acid level<360μmol/L)according to the serum uric acid level of the women.The hypertension grades of the women in the two groups were statistically analyzed.The correlation between the serum uric acid level of the women with HDP and their values of systolic and diastolic blood pressure was analyzed by Pearson correlation analysis.Multivariate Logistic regression analysis was used to evaluate the predictive value of the serum uric acid of the women with HDP for their preeclampsia occurrence.Results:The grade of HDP of the women in group A was significantly higher than that of the women in the group B.The level of serum uric acid of the women with HDP was positively correlated with their values of systolic and diastolic blood pressure.The proportion of the serum uric acid≥360μmol/L(81.0%)of the women with PE was significantly higher than that(38.0%)of the women without PE(all P<0.05).Multivariate regression analysis showed that the serum uric acid≥360μmol/L,the age≥35 years old,the pre-pregnancy body mass index≥28kg/m^(2),the family history of PE,and the previous history of PE of the women with HDP were all the independent risk factors of their PE occurrence(all P<0.05).Conclusion:The serum uric acid level of the women with HDP is positively correlated with their severity of HDP,and which is the independent risk factors of their PE occurrence.