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Multifunctional nanocomposites modulating the tumor microenvironment for enhanced cancer immunotherapy

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摘要 Cancer immunotherapy has gained momentum for treating malignant tumors over the past decade.Checkpoint blockade and chimeric antigen receptor cell therapy(CAR-T)have shown considerable potency against liquid and solid cancers.However,the tumor microenvironment(TME)is highly immunosuppressive and hampers the effect of currently available cancer immunotherapies on overall treatment outcomes.Advancements in the design and engineering of nanomaterials have opened new avenues to modulate the TME.Progress in the current nanocomposite technology can overcome immunosuppression and trigger robust immunotherapeutic responses by integrating synergistic functions of different molecules.We will review recent advancements in nanomedical applications and discuss specifically designed nanocomposites modulating the TME for cancer immunotherapy.In addition,we provide information on the current landscape of clinical-stage nanocomposites for cancer immunotherapy.
出处 《Bioactive Materials》 SCIE CSCD 2024年第1期440-462,共23页 生物活性材料(英文)
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