Nanomotor-based H_(2)S donor with mitochondrial targeting function for treatment of Parkinson’s disease

Reduction of endogenous hydrogen sulfide(H_(2)S)is considered to have an important impact on the progress of Parkinson’s disease(PD),thus exogenous H_(2)S supplementation is expected to become one of the key means to treat PD.However,at present,it is difficult for H_(2)S donors to effectively penetrate the blood brain barrier(BBB),selectively release H_(2)S in brain,and effectively target the mitochondria of neuron cells.Herein,we report a kind of nanomotor-based H_(2)S donor,which is obtained by free radical polymerization reaction between L-cysteine derivative modified-polyethylene glycol(PEG-Cys)and 2-methacryloyloxyethyl phosphorylcholine(MPC).This kind of H_(2)S donor can not only effectively break through BBB,but also be specifically catalyzed by cystathionineβ-synthase(CBS)in neurons of PD site in brain and 3-mercaptopyruvate sulfurtransferase(3-MST)in mitochondria to produce H_(2)S,endowing it with chemotaxis/motion ability.Moreover,the unique chemotaxis effect of nanomotor can realize the purpose of precisely targeting brain and the mitochondria of damaged neuron cytopathic diseases.This kind of nanomotor-based H_(2)S donor is expected to enrich the current types of H_(2)S donors and provide new ideas for the treatment of PD.