增液颗粒对妊娠母猪的安全性试验

Safety Test of Zengye Granules in Pregnant Sows

为评价治疗妊娠母猪便秘的中兽药增液颗粒对母猪的安全性,以指导临床安全合理用药。选择体况、胎次、预产期相近的妊娠90 d以上的母猪32头,随机分为4组,各剂量组分别按照20、60、100 g/kg饲料添加剂量饲喂增液颗粒,空白对照组给予常规饲料。连续给药7 d,给药后连续观察21 d。通过检测母猪的临床体征、血液生理生化指标、生产性能,考察增液颗粒对母猪及胎儿的安全性。结果显示,增液颗粒给药组妊娠母猪采食量、呼吸次数、体温、生产性能与空白对照组相比均无显著差异(P>0.05);测定给药前后各组母猪血常规及血清生化指标,部分指标在给药前后与空白对照组比较差异显著(P<0.05),但并不呈现剂量依赖性。综合各项数据表明,增液颗粒临床推荐剂量5倍以下给药对妊娠母猪是安全的。

To evaluate the safety of Chinese veterinary medicine Zengye granules for treating constipation in pregnant sows and guide clinical safe and rational drug use,thirty-two sows with similar body condition,parity,and expected delivery date over 90 days of pregnancy were randomly divided into 4 groups.Each dose group was fed with Zengye granules at doses of 20 g/kg,60 g/kg,and 100 g/kg of feed,while the control group was given with conventional feed,for continuous administration for 7 days,followed by continuous observation for 21 days.The clinical signs,blood physiological and biochemical indicators,and production performance of sows were detected to assess the safety of Zengye granules on sows and fetuses.The experimental results showed that there were no significant differences in feed intake,respiratory rate,body temperature,and production performance between the pregnant sows in the groups treated with Zengye granules and the control group(P>0.05).Blood routine and serum biochemical indicators of each group of sows were measured before and after administration,and some indicators showed significant differences compared to the control group(P<0.05),but did not show dose dependence.Based on comprehensive data,it is safe and non-toxic for pregnant sows to administer Zengye granules at a clinical recommended dose of less than 5 times.