CONUT评分联合CA125对乳腺癌术后患者复发的预测价值

Predictive value of CONUT score combined with CA125 for postoperative recurrence of breast cancer

目的:探讨CONUT评分联合CA125对乳腺癌术后患者复发的预测价值。方法:选取2018年1月-2021年1月枣庄市妇幼保健院经乳腺癌根治术150例患者,失访6例,共纳入144例患者作为研究对象。根据患者术后2年的复发情况分为复发组(50例)和未复发组(94例)。收集患者一般临床资料及相关标本采集。应用ROC曲线分析CONUT评分、CA125对乳腺癌术后患者复发的预测价值。采用Cox比例分析模型分析影响乳腺癌术后患者复发的危险因素。结果:CONUT评分、CA125以及两者联合预测乳腺癌术后患者复发的曲线下面积分别为0.715、0.798、0.864,敏感度分别为54.0%、82.0%、81.9%,特异度分别为90.4%、67.0%、80.0%。多因素Cox回归分析,淋巴结转移、T分期、COUNT评分和CA125均为影响乳腺癌术后患者复发的独立危险因素;且高CONUT评分组、高CA125组患者复发率高于低CONUT评分组、低CA125组,差异均有统计学意义(P<0.05)。结论:淋巴结转移、T分期、CONUT评分以及CA125均是影响乳腺癌术后患者复发的危险因素。CONUT评分联合CA125可以更准确预测乳腺癌术后复发风险,为制定个体化的后续治疗策略提供依据。

Objective:To explore the predictive value of CONUT score combined with CA125 in postoperative breast cancer patients.Methods:From January 2018 to January 2021,Zaozhuang Maternal and Child Health Care Hospital selected 150 patients who had undergone radical surgery for breast cancer,6 patients were lost to follow-up,and 144 patients were included as the study subjects.According to the recurrence rate of patients 2 years after surgery,they were divided into a recurrence group(50 cases)and a non recurrence group(94 cases):Collect general clinical data and relevant specimens from patients.The ROC curve was used to analyze the predictive value of CONUT score and CA125 for postoperative recurrence of breast cancer.Cox proportional analysis model was used to analyze the risk factors ffecting the recurrence ofbreast cancer patients after surgery.Results:The area under the curve ofCONUT score,CA125 and their combination for predicting postoperative recurrence of breast cancer patients were 0.715,0.798 and 0.864,respectively,with sensitivity of 54.0%,82.0%and 81.9%,and specificity of 90.4%,67.0%and 80.0%,respectively.Multivariate Cox regression analysis showed that lymph node metastasis,T stage,COUNT score and CA125 were independent risk factors for recurrence of breast cancer patients after surgery,Moreover,the recurrence rate of patients in the high CONUT score group and high CA125 group was higher than that in the low CONUT score group and low CA125 group,with statistical significance(P<0.05).Conclusion:Lymph node metastasis,T stage,CONUT score and CA125 are risk factors for recurrence of postoperative breast cancer patients.CONUT score combined with CA125 can more accurately predict the risk of postoperative recurrence of breast cancer,and provide a basis for formulating individualized follow-up treatment strategies.