中医辨证治疗失眠对抑郁症早期干预的研究

Study on early intervention of insomnia in depression treated by TCM syndrome differentiation treatment

目的观察中医辨证治疗失眠对抑郁症状及血清白细胞介素(interleukin,IL)-6和肿瘤坏死因子(tumor necrosis factor,TNF)-α的影响,进而讨论中医辨证治疗失眠对于减少抑郁症发生、发展的效果。方法选取2020年9月至2022年7月就诊于杭州市中医院的失眠障碍患者60例作为研究对象,按患者治疗意愿将60例失眠障碍患者分为干预组和空白组,每组30例,分别予以睡眠卫生宣教及中医辨证治疗和单独睡眠卫生宣教。比较两组患者的睡眠、抑郁情绪及血清IL-6和TNF-α含量的变化。结果干预2个月后,干预组患者的匹兹堡睡眠质量指数量表(Pittsburgh sleep quality index,PSQI)评分、抑郁症筛查量表(patient health questiomnare-9,PHQ-9)评分、中医症候积分明显下降,血清中IL-6和TNF-α的含量也降低,差异有统计学意义(P<0.05)。结论中医辨证治疗可有效改善失眠及抑郁情绪,从而延缓抑郁症的发生、发展,是早期干预抑郁症的有效方法。

Objective To observe the effect of traditional Chinese medicine(TCM)syndrome differentiation treatment of insomnia on depressive symptoms and interleukin(IL)-6 level and tumor necrosis factor(TNF)-αlevel in serum.And then to discuss the effect of TCM syndrome differentiation treatment of insomnia on reducing the occurrence and development of depression.Methods Sixty patients with insomnia disorder in Hangzhou Hospital of Traditional Chinese Medicine from September 2020 to July 2022 were selected as research objects,and they were divided into intervention group and blank group 30 patients for each group,according to their treatment intention and they were treated with sleep hygiene education plus TCM syndrome differentiation treatment and sleep hygiene education alone respectively.The changes of sleep,depression,serum IL-6 level and TNF-αlevel were compared between two groups.Results After 2 weeks of intervention,the intervention group’s Pittsburgh sleep quality index score,patient health questiomnare-9 score,TCM symptom score,and serum IL-6 and TNF-αlevel were all significantly reduced,and the difference was statistically significant(P<0.05).Conclusion TCM syndrome differentiation treatment can effectively improve insomnia and depression,thus delaying the occurrence and development of depression,and is an effective method for early intervention of depression.