氨氯地平联合替米沙坦治疗社区老年高血压患者的效果分析

Effect analysis of amlodipine combined with telmisartan on elderly patients with hypertension in community

目的探讨氨氯地平与替米沙坦联合治疗社区老年高血压的效果,为临床应用提供依据。方法将70例社区老年高血压患者纳入研究,基于随机数字表法分成对照组和实验组,各35例。对照组应用苯磺酸氨氯地平治疗,实验组在对照组用药基础上联用替米沙坦治疗。比较两组治疗前后血压水平,疗效,用药不良反应发生情况。结果治疗后,两组收缩压(SBP)、舒张压(DBP)、24 h平均DBP、24 h平均SBP均较治疗前降低,且实验组显著低于对照组(P<0.05);但两组治疗前后收缩压波动性(SBPV)、舒张压波动性(DBPV)组间组内均无显著差异(P>0.05);治疗后,实验组的总有效率为94.29%,显著高于对照组的77.14%(P<0.05)。用药期间,实验组和对照组患者的不良反应发生率分别为8.57%、11.43%,比较无显著差异(P>0.05)。结论氨氯地平联合替米沙坦治疗社区老年高血压患者,能更好控制和稳定地降血压,提高治疗效果,且有着良好安全性,有重要的临床意义。

Objective To explore the effect of amlodipine combined with telmisartan on elderly patients with hypertension in community,so as to provide basis for clinical application.Methods A total of 70 elderly patients with hypertension in community were enrolled in the study,and were divided into a control group and an experimental group according to random numerical table,with 35 cases in each group.The control group was treated with amlodipine,and the study group was treated with telmisartan on the basis of the control group.The blood pressure before and after treatment,efficacy,and adverse drug reactions were compared between the two groups.Results After treatment,the systolic blood pressure(SBP),diastolic blood pressure(DBP),24 h mean DBP,24 h mean SBP in both groups were lower than those before treatment,and the experimental group was significantly lower than the control group(P<0.05).However,there was no significant difference in systolic blood pressure variability(SBPV)and diastolic blood pressure variability(DBPV)between the two groups before and after treatment between and within the two groups(P>0.05).After treatment,the total effective rate of the experimental group was 94.29%,which was significantly higher than 77.14%of the control group(P<0.05).During the medication period,the incidence rate of adverse reactions in the experimental group and the control group was 8.57%and 11.43%,respectively,and there was no significant difference in comparison(P>0.05).Conclusion The application of amlodipine combined with telmisartan in the treatment of elderly patients with hypertension in community can better control and stabilize blood pressure,improve treatment effect,and have good safety,which has important clinical significance.