盐酸贝那普利联合螺内酯治疗对糖尿病合并心衰患者血糖及心功能的影响

Effect of benazepril hydrochloride combined with spironolactone on blood glucose and cardiac function in diabetic patients with heart failure

目的分析盐酸贝那普利联合螺内酯治疗对糖尿病合并心力衰竭(心衰)患者血糖及心功能的影响。方法60例糖尿病合并心衰患者,将其随机分成对照组与研究组,各30例。全部患者均接受常规对症治疗,对照组在常规对症治疗的基础上采用盐酸贝那普利口服治疗,研究组则在常规对症治疗的基础上采用盐酸贝那普利联合螺内酯治疗。比较两组患者血糖指标、心功能指标、临床疗效。结果相较于治疗前,两组患者治疗后的糖化血红蛋白(HbA1c)、空腹血糖(FPG)以及餐后2 h血糖(2 h PG)水平均明显下降,且研究组HbA1c(5.77±0.66)%、FPG(5.83±0.55)mmol/L、2 h PG(7.09±0.51)mmol/L均显著低于对照组的(6.22±0.83)%、(6.21±0.52)mmol/L、(7.58±0.57)mmol/L(P<0.05)。相较于治疗前,两组患者治疗后的左室收缩末期容积(LVESV)、左室舒张末期容积(LVEDV)明显下降,左室射血分数(LVEF)则明显升高,且研究组患者的LVESV(51.41±9.15)ml、LVEDV(104.24±115.81)ml明显低于对照组的(60.23±8.27)、(115.81±10.45)ml,LVEF(55.03±45.13)%则明显高于对照组的(45.13±3.35)%(P<0.05)。与对照组的73.33%相比,研究组治疗总有效率93.33%更高(P<0.05)。结论糖尿病合并心衰患者接受盐酸贝那普利联合螺内酯治疗能对其血糖水平进行有效控制,并对其心功能改善效果显著,值得推广。

Objective To analyze the effect of benazepril hydrochloride combined with spironolactone on blood glucose and cardiac function in diabetic patients with heart failure.Methods 60 cases of diabetic patients with heart failure were randomly divided into a control group and a study group,with 30 cases in each group.All patients received conventional symptomatic treatment.On this basis,the control group received oral benazepril hydrochloride,and the study group received combined treatment with benazepril hydrochloride and spironolactone.The blood glucose indicators,cardiac function indicators and clinical efficacy were compared between the two groups.Results Compared with before treatment,the levels of glycosylated hemoglobin(HbA1c),fasting plsma glucose(FPG)and 2 h postprandial glucose(2 h PG)in both groups were significantly decreased after treatment;the study group had HbA1c of(5.77±0.66)%,FPG of(5.83±0.55)mmol/L and 2 h PG of(7.09±0.51)mmol/L,which were significantly lower than(6.22±0.83)%,(6.21±0.52)mmol/L and(7.58±0.57)mmol/L in the control group(P<0.05).Compared with before treatment,the left ventricular end-systolic volume(LVESV)and left ventricular end-diastolic volume(LVEDV)in both groups were significantly decreased after treatment,while the left ventricular ejection fraction(LVEF)was significantly increased;the study group had LVESV of(51.41±9.15)ml and LVEDV of(104.24±115.81)ml,which were significantly lower than(60.23±8.27)and(115.81±10.45)ml in the control group;LVEF of(55.03±45.13)%in the study group was significantly higher than(45.13±3.35)%in the control group(P<0.05).Compared with 73.33%in the control group,the total effective rate of 93.33%in the study group was higher(P<0.05).Conclusion Benazepril hydrochloride combined with spironolactone can effectively control blood glucose level and improve cardiac function in diabetic patients with heart failure,which is worthy of promotion.