醋酸亮丙瑞林联合腹腔镜子宫肌瘤剔除术对子宫肌瘤FSH、E_(2)及LH水平的影响

The effect of leuprolide acetate combined with laparoscopic myomectomy on FSH,E_(2),LH levels in patients with uterine fibroids

目的对子宫肌瘤患者实施醋酸亮瑞林、腹腔镜子宫肌瘤剔除术(LSM)联合方案,观察该联合方案对卵泡刺激素(FSH)、雌二醇(E_(2))、促黄体生成素(LH)水平的影响。方法选取100例子宫肌瘤患者,根据治疗方案的个体差异性分为对照组(LSM治疗)、观察组(醋酸亮丙瑞林+LSM治疗),各50例。比较两组血清性激素水平、术后月经指标及围术期相关治疗指标。结果治疗前,对照组血清FSH、E_(2)、LH水平分别为(27.57±3.47)U/L、(275.39±33.48)pmol/L、(20.91±2.51)U/L,观察组分别为(27.61±3.36)U/L、(276.82±33.51)pmol/L、(20.85±2.49)U/L;治疗后,对照组血清FSH、E_(2)、LH水平分别为(18.17±2.84)U/L、(216.17±26.57)pmol/L、(17.49±1.85)U/L,观察组分别为(13.05±2.29)U/L、(139.84±18.79)pmol/L、(11.67±1.36)U/L。与治疗前相比,两组血清FSH、E_(2)、LH水平均明显下降,组内差异有统计学意义(P<0.05);观察组治疗后血清FSH、E_(2)、LH水平均低于对照组,组间差异有统计学意义(P<0.05)。观察组术后月经周期时间(29.56±1.32)d短于对照组的(33.13±2.29)d,月经量(41.33±4.32)ml少于对照组的(55.45±6.69)ml,组间差异有统计学意义(P<0.05)。观察组术中出血量、盆腔引流量少于对照组,下床活动时间、住院时间短于对照组,疾病复发率低于对照组,组间差异有统计学意义(P<0.05)。结论醋酸亮丙瑞林联合LSM运用于子宫肌瘤临床治疗过程中,可明显降低患者FSE、E_(2)、LH水平,减少术中出血量与盆腔引流量,加快术后身体恢复,降低疾病复发率,值得推荐。

Objective To observe the effect of leuprolide acetate combined with laparoscopic myomectomy(LSM)on follicle stimulating hormone(FSH),estradiol(E_(2)),luteinizing hormone(LH)levels in patients with uterine fibroids.Methods A total of 100 patients with uterine fibroids were selected and divided into a control group(LSM treatment)and an observation group(leuprolide acetate+LSM treatment)according to individual differences in treatment plans,each with 50 cases.The serum sex hormone levels,postoperative menstrual indicators and perioperative related therapeutic indicators were compared between the two groups.Results Before treatment,the serum levels of FSH,E_(2),and LH were(27.57±3.47)U/L,(275.39±33.48)pmol/L,and(20.91±2.51)U/L in the control group,and(27.61±3.36)U/L,(276.82±33.51)pmol/L,and(20.85±2.49)U/L in the observation group,respectively.After treatment,the serum levels of FSH,E_(2),and LH were(18.17±2.84)U/L,(216.17±26.57)pmol/L,and(17.49±1.85)U/L in the control group,and(13.05±2.29)U/L,(139.84±18.79)pmol/L,and(11.67±1.36)U/L in the observation group,respectively.Compared with those before treatment,the serum levels of FSH,E_(2)and LH decreased significantly in both groups,and the difference within the groups was statistically significant(P<0.05).After treatment,the serum levels of FSH,E_(2)and LH in the observation group were lower than those in the control group,and the difference between the groups was statistically significant(P<0.05).The duration of postoperative menstrual cycle of(29.56±1.32)d in the observation group was shorter than(33.13±2.29)d in the control group,and the menstrual amount of(41.33±4.32)ml was less than(55.45±6.69)ml in the control group.The difference between the groups was statistically significant(P<0.05).The intraoperative bleeding volume and pelvic drainage in the observation group were less than those in the control group;the off-bed ambulation time and hospital stay in the observation group was shorter than those in the control group;the disease recurrence rate in the observation group was lower than that in the control group;the difference between the groups was statistically significant(P<0.05).Conclusion The combination of leuprolide acetate and LSM can significantly reduce the levels of FSE,E_(2),and LH in the clinical treatment of uterine fibroids,reduce intraoperative bleeding volume and pelvic drainage,accelerate postoperative recovery,and reduce disease recurrence rate.It is worthy of recommendation.