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连蒲清热燥湿方联合泮托拉唑对消化性溃疡患者PYY、IFN-γ及胃酸分泌功能的影响

Effects of Lianpu Qingre Zaoshi Recipe combined with pantoprazole on PYY,IFN-γand gastric acid secretion in patients with peptic ulcer
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摘要 目的探讨连蒲清热燥湿方联合泮托拉唑对消化性溃疡患者肽YY(PYY)、干扰素γ(IFN-γ)及胃酸分泌功能的影响。方法105例消化性溃疡患者,采用随机数字表法分为试验组(53例)和对照组(52例)。对照组给予泮托拉唑治疗,试验组在对照组基础上加用连蒲清热燥湿方治疗。比较两组疗效,治疗前后血清PYY、IFN-γ、胃酸分泌功能[基础胃酸分泌量(BAO)、最大胃酸分泌量(MAO)、高峰胃酸分泌量(PAO)],临床症状改善时间及不良反应发生情况。结果试验组总有效率90.57%高于对照组的75.00%,差异显著(P<0.05)。治疗后,两组血清PYY、IFN-γ水平均较本组治疗前降低,且试验组血清PYY、IFN-γ水平分别为(1.12±0.21)pmol/L、(140.12±17.35)ng/ml,低于对照组的(1.42±0.27)pmol/L、(163.31±16.58)ng/ml,差异显著(P<0.05)。治疗后,两组BAO、MAO、PAO均较本组治疗前降低,且试验组BAO、MAO、PAO分别为(4.01±0.52)、(8.01±2.12)、(11.34±3.21)mmol/h,低于对照组的(5.16±0.63)、(10.21±2.39)、(14.54±3.65)mmol/h,差异显著(P<0.05)。试验组腹痛改善时间(1.82±0.33)d、反酸改善时间(2.38±0.30)d、上腹灼烧感改善时间(2.13±0.37)d短于对照组的(3.64±0.49)、(4.15±0.57)、(3.75±0.51)d,差异显著(P<0.05)。两组不良反应发生率比较无显著差异(P>0.05)。结论在消化性溃疡治疗中应用连蒲清热燥湿方联合泮托拉唑疗效显著,可能与其可有效改善PYY、IFN-γ水平及胃酸分泌功能有关。 Objective To explore the effects of Lianpu Qingre Zaoshi Recipe combined with pantoprazole on peptide YY(PYY),interferon-γ(IFN-γ)and gastric acid secretion in patients with peptic ulcer.Methods 105 patients with peptic ulcer were divided into an experimental group(53 cases)and a control group(52 cases)by random numerical table.The control group was given pantoprazole treatment,and the experimental group was treated with Lianpu Qingre Zaoshi Recipe on the basis of the control group.Both groups were compared in terms of efficacy,serum PYY,IFN-γ,gastric acid secretion function[basal acid output(BAO),maximal acid output(MAO)and peak acid output(PAO)]before and after treatment,improvement time of clinical symptoms,and the occurrence of adverse reactions.Results The total effective rate of 90.57%in the experimental group was higher than 75.00%in the control group,and the difference was significant(P<0.05).After treatment,the serum levels of PYY and IFN-γin both groups were lower than those before treatment;the serum levels of PYY and IFN-γwere(1.12±0.21)pmol/L and(140.12±17.35)ng/ml in the experimental groups,which were lower than(1.42±0.27)pmol/L and(163.31±16.58)ng/ml in the control group;and the differences were significant(P<0.05).After treatment,BAO,MAO and PAO in both groups were lower than those before treatment;BAO,MAO and PAO were(4.01±0.52),(8.01±2.12)and(11.34±3.21)mmol/h in the experimental group,which were lower than(5.16±0.63),(10.21±2.39)and(14.54±3.65)mmol/h in the control group;and the differences were significant(P<0.05).The improvement time of abdominal pain,acid reflux and epigastric burning sensation were(1.82±0.33),(2.38±0.30)and(2.13±0.37)d in the experimental group,which were shorter than(3.64±0.49),(4.15±0.57)and(3.75±0.51)d in the control group,and the differences were significant(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion Lianpu Qingre Zaoshi Recipe combined with pantoprazol has significant effect in the treatment of peptic ulcer,which may be related to the effective improvement of PYY,IFN-γlevels and gastric acid secretion.
作者 黄晓 HUANG Xiao(Department of General Practice Medicine,Xindian Town Health Center of Jin'an District,Fuzhou 350011,China)
出处 《中国现代药物应用》 2024年第21期143-146,共4页 Chinese Journal of Modern Drug Application
关键词 连蒲清热燥湿方 泮托拉唑 消化性溃疡 肽YY 干扰素Γ 胃酸分泌功能 Lianpu Qingre Zaoshi Recipe Pantoprazole Peptic ulcer Peptide YY Interferon-γ Gastric acid secretion
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