活血止痛合剂治疗闭合性胫骨干骨折初期炎症反应的疗效观察

Effect of Huoxue Zhitong Mixture on Initial Inflammatory Reaction of Closed Tibial Shaft Fracture

目的观察活血止痛合剂治疗闭合性胫骨干骨折初期炎症反应的临床疗效。方法将64例患者按随机数字表法分为两组,对照组给予口服地奥司明及艾瑞昔布治疗,研究组给予口服活血止痛合剂治疗。记录两组治疗前后肿胀程度、视觉模拟量表(VAS)评分和炎性指标包括白细胞计数(WBC)、白细胞介素-6(IL-6)、C反应蛋白(CRP)水平。同时记录治疗后皮肤皱纹征的出现时间、术前时间以及临床疗效,进行安全性评价,对数据进行统计分析。结果治疗1 d后,两组的肿胀值、疼痛评分、WBC、IL-6和CRP水平均高于治疗前(P<0.01)。治疗3、5 d后,两组肿胀值、疼痛评分、WBC、IL-6、CRP水平较前或治疗1 d均下降(P<0.01),且上述时间点研究组均低于对照组(P<0.01)。治疗5 d后,研究组在皮肤皱纹征出现时间及术前时间上比对照组提前(P<0.01),研究组的总有效率为87.50%,高于对照组的68.75%(P<0.05)。两组均无严重不良事件发生。结论活血止痛合剂能够有效改善闭合性胫骨干骨折初期患者肿痛症状,控制炎症反应,缩短术前时间,未见严重不良反应。

Objective:To observe the clinical effect of Huoxue Zhitong Mixture on the initial inflammatory reaction of closed tibial shaft fracture.Methods:A total of 64 patients were randomly divided into control group(32 case,treated with oral diosmin tablets and imrecoxib tablets)and study group(32 cases,treated with oral Huoxue Zhitong Mixture)using a random number tablemethod.The swelling degree,VAS pain score and inflammatory markers,including white blood cell count(WBC),interleukin-6(IL-6)and C-reactive protein(CRP)levels in the two groups were recorded at different periods.At the same time,the appearance time of skin wrinkles after treatment,preoperative time and clinical efficacy were recorded,the safety evaluation was carried out,and the data were statistically analyzed.Results:On day 1 after treatment,the swelling values,pain scores,WBC,IL-6 and CRP levels in both groups were higher than before treatment(P<0.01).On day 3 and day 5 after treatment,swelling,pain score,WBC,IL-6 and CRP levels in both groups were decreased compared with before treatment or day 1 after treatment(P<0.01),and the above time points in the study group were lower than those in the control group(P<0.05).On the 5th day of treatment,the appearance time and preoperative time of skin wrinkles in the study group were earlier than those in the control group(P<0.05).The total effective rate of the study group was 87.50%,which was higher than 68.75%of the control group(P<0.05).No serious adverse events occurred in either group.Conclusion:Huoxue Zhitong Mixture can effectively improve the symptoms of swelling and pain in the early stage of closed tibial shaft fracture,control inflammatory reaction,shorten the preoperative time,and no serious adverse reactions.