回顾性研究降脂清胰汤治疗高脂血症性急性胰腺炎的临床疗效

Clinical Efficacy of Jiangzhi Qingyi Decoction in Treating Hyperlipidemic Acute Pancreatitis

目的回顾性研究降脂清胰汤治疗高脂血症性急性胰腺炎(HTG-AP)的临床疗效及对血脂、血清炎症因子及淀粉酶水平的影响。方法将90例患者按照治疗方法不同分为观察组与对照组各45例,其中对照组给予西医常规治疗,观察组在对照组基础上加用降脂清胰汤治疗。治疗1周后,比较两组治疗前后中医证候评分,胃肠功能恢复情况,治疗前后血脂及淀粉酶、脂肪酶指标、血清炎症因子水平和治疗总有效率。结果治疗后观察组总有效率为91.11%,显著高于对照组的71.11%,两组比较差异具有统计学意义(P<0.05)。观察组治疗后中医证候评分、腹痛缓解时间、排气时间、排便时间及肠鸣音恢复时间显著短于对照组(P<0.05)。两组患者治疗后血淀粉酶、总胆固醇、三酰甘油、C反应蛋白、降钙素原、白细胞介素-6水平均低于治疗前,且观察组患者效果更优(P<0.05)。结论降脂清胰汤治疗HTG-AP效果显著,疗效确切,能够有效提高治疗总有效率,调节血脂、抑制炎症反应及改善淀粉酶水平,促进胃肠功能恢复并有助于患者术后快速康复。

Objective:To observe the clinical efficacy of Jiangzhi Qingyi Decoction in the treatment of hyperlipidemic acute pancreatitis(HTG-AP)and its effects on blood lipids,serum inflammatory factors,and amylase levels.Methods:Totally 90 patients who met the inclusion criteria were divided into an observation group(n=45)and a control group(n=45)according to different treatment methods.The control group was given routine western medicine treatment,while the observation group was treated with Jiangzhi Qingyi Decoction in addition to the control group.The TCM syndrome scores,gastrointestinal function recovery status,lipid levels,amylase and lipase indicators,and serum inflammatory factor levels were compared before and after treatment in both groups.Results:After treatment,the overall effective rate in the observation group was significantly higher than that in the control group,with statistical significance(P<0.05).The observation group showed significantly shorter times for relief of abdominal pain,resumption of flatus passage,defecation,and bowel sounds compared with the control group(P<0.05).After treatment,the serum amylase,total cholesterol,triglycerides,C-reactive protein,procalcitonin,and interleukin-6 levels were lower than before treatment in both groups,with the observation group demonstrating better results(P<0.05).Conclusion:Jiangzhi Qingyi Decoction is highly effective in treating HTG-AP,enhancing the overall effective rate,regulating lipid levels,inhibiting inflammatory responses,and improving amylase levels,promoting the recovery of gastrointestinal function and aiding rapid postoperative recovery of patients.