布地奈德雾化吸入联合止嗽散穴位敷贴治疗小儿支气管肺炎的效果

Effect of budesonide atomization inhalation combined with Zhisou San acupoint application in the treatment of children with bronchopneumonia

目的分析布地奈德雾化吸入联合止嗽散穴位敷贴治疗小儿支气管肺炎的效果。方法选取就诊的支气管肺炎患儿80例作为研究对象,随机分成对照组和观察组,每组40例。对照组给予布地奈德雾化吸入治疗,观察组在对照组治疗的基础上给予止嗽散穴位敷贴。比较2组患儿的临床疗效、肺炎症状积分、主要症状消退时间、肺功能指标、T淋巴细胞亚群(CD3^(+)、CD4^(+)、CD8^(+)和CD4^(+)/CD8^(+))水平、血清炎性细胞因子[白细胞介素-6(interleukin-6,IL-6)、γ干扰素(interferon-γ,IFN-γ)、白细胞介素-1β(interleukin-1β,IL-1β)]及不良反应的发生情况。结果治疗后,观察组的总有效率高于对照组(P<0.05);观察组的症状积分低于对照组(P<0.05);观察组的恢复时间短于对照组(P<0.05);观察组的第1秒用力呼气容积(forced expiratory volume in one second,FEV1)、最大肺活量(maximum vital capacity,VCmax)和第1秒用力呼气占用力肺活量(forced vital capacity,FVC)比率(FEV1/FVC)均高于对照组(P<0.05);2组患儿的CD4^(+)、CD4^(+)/CD8^(+)和CD3^(+)水平较治疗前均升高(P<0.05),CD8^(+)水平均降低(P<0.05),且观察组改善的幅度均大于对照组(P<0.05);2组患儿的血清IL-6、IFN-γ和IL-1β水平均降低(P<0.05),且观察组均低于对照组(P<0.05);2组不良反应总发生率比较差异无统计学意义(P>0.05)。结论布地奈德雾化吸入联合止嗽散穴位敷贴治疗小儿支气管肺炎,可改善患儿的临床症状及肺功能,降低症状积分,促进患儿恢复,还可提高患儿的免疫功能,降低患儿的血清炎性细胞因子水平,且不增加不良反应。

Objective To analyze the effect of aerosol inhalation of budesonide combined with Zhisou San acupoint application in the treatment of children with bronchopneumonia.Methods 80 children with bronchopneumonia who received medical treatment were selected as the research subjects and randomly divided into a control group and an observation group,with 40 cases in each group.The control group was given budesonide atomization inhalation treatment,while the observation group was given Zhisou San acupoint application treatment on the basis of the control group.The clinical efficacy,pneumonia symptom score,main symptom resolution time,lung function indicators,T lymphocyte subsets(CD3^(+),CD4^(+),CD8^(+)and CD4^(+)/CD8^(+))levels,serum inflammatory cytokines[interleukin-6(IL-6),interferon-γ(IFN-γ),and interleukin-1β(IL-1β)],and the incidence of adverse reactions between the 2 groups were compared.Results After treatment,the total effective rate of the observation group was higher than that of the control group(P<0.05);the symptom score of the observation group was lower than that of the control group(P<0.05);The recovery time of the observation group was shorter than that of the control group(P<0.05);the forced expiratory volume in one second(FEV1),maximum vital capacity(VCmax),and the ratio of forced expiratory volume to forced vital capacity(FVC)in the observation group were all higher than those in the control group(P<0.05);the CD4^(+),CD4^(+)/CD8^(+)and CD3^(+)increased in both groups of patients compared with before treatment(P<0.05),while CD8^(+)decreased(P<0.05),and the improvement in the observation group was greater than that in the control group(P<0.05).The serum levels of IL-6,IFN-γand IL-1βin the 2 groups were decreased(P<0.05),and the observation group was lower than the control group(P<0.05).The total incidence of adverse reactions showed no significant difference between the 2 groups(P>0.05).Conclusion Budesonide atomization inhalation combined with Zhisou San acupoint application for children with bronchial pneumonia has a significant effect,which can improve children’s clinical symptoms and pulmonary function,reduce symptom scores,promote children’s recovery,improve children’s immune function,and reduce the serum inflammatory cytokine levels in children without increasing adverse reactions.