矛头蝮蛇血凝酶联合奥美拉唑治疗上消化道出血患者的疗效

Efficacy of haemocoagulase from Agkistrodon acutus combined with omeprazole in patients with upper digestive tract hemorrhage

目的探讨矛头蝮蛇血凝酶联合奥美拉唑治疗上消化道出血患者的疗效及对炎症和血液流变学的影响。方法选取收治的106例上消化道出血患者作为研究对象,用随机数字表法分为观察组和对照组,每组53例。对照组予以奥美拉唑治疗,观察组在对照组治疗的基础上予以矛头蝮蛇血凝酶治疗。比较2组患者的临床疗效、炎症因子水平、血液流变学以及临床指标。结果观察组的临床有效率为94.34%,高于对照组(81.13%),P<0.05;治疗后,与对照组比较,观察组的超敏C反应蛋白(high sensitive C-reactive protein,hs-CRP)、肿瘤坏死因子-α(tumour necrosis factor-α,TNF-α)和白细胞介素-6(interleukin-6,IL-6)水平显著下降(P<0.05);红细胞沉降率显著降低(P<0.05),红细胞压积、全血高切黏度和全血低切黏度明显升高(P<0.05),止血时间、住院时间明显缩短(P<0.05),复发率明显降低(P<0.05)。结论矛头蝮蛇血凝酶联合奥美拉唑治疗上消化道出血能提高临床疗效,改善患者的临床指标和血液流变学,缓解炎症反应。

Objective To investigate the efficacy of haemocoagulase from Agkistrondon acutus combined with omeprazole in patients with upper digestive tract hemorrhage and the effects on inflammation and hemorheology.Methods A total of 106 patients with upper digestive tract hemorhage admitted to our hospital were randomly divided into an observation group(n=53)and a control group(n=53).The control group was treated with omeprazole,while the observation group was treated with haemocoagulase from Agkistrodon acutus in addition.The clinical efficacy,the levels of inflammatory factors,hemorheology and clinical indicators were compared between the 2 groups before and after treatment.Results The clinical effective rate of the observation group(94.34%)was higher than that of the control group(81.13%),P<0.05.After treatment,the levels of high sensitive C-reactive protein(hs-CRP),tumour necrosis factor-α(TNF-α)and interleukin-6(IL-6)in the observation group decreased more significantly than those in the control group(P<0.05).The erythrocyte sedimentation rate in the observation group was lower than that in the control group(P<0.05),and the hematocrit,whole blood high shear viscosity and whole blood low shear viscosity were higher than those in the control group(P<0.05).The hemostasis time and hospitalization time in the observation group were shorter than those in the control group(P<0.05),and the recurrence rate was lower than that in the control group(P<0.05).Conclusion The hemocoagulase therapy is beneficial to patients with upper gastrointestinal bleeding,which can improve the clinical efficacy,clinical indicators and hemorheology,and relieve inflammation.