甘草酸二铵胶囊治疗老年肝功能不全患者的效果

Effect of Diammonium Glycyrrhizinate Capsules in the treatment of elderly hepatic insufficiency

目的探究用甘草酸二铵胶囊治疗老年肝功能不全患者的疗效。方法将104例老年肝功能不全患者按照随机数字表法分为对照组和观察组,每组52例。对照组给予常规治疗,观察组在对照组治疗的基础上口服甘草酸二铵胶囊。比较2组患者的临床疗效和不良反应发生率,比较2组患者治疗前后的肝功能[丙氨酸氨基转移酶(alanine aminotransferase,ALT)、天冬氨酸氨基转移酶(aspartate aminotransferase,AST)、总胆红素(total bilirubin,TBiL)]、炎症因子[C反应蛋白(C-reactive protein,CRP)、中性粒细胞计数(neutrophil count,NEUT)、白细胞计数(white blood cell count,WBC)]、应激反应[丙二醛(malondialdehyde,MDA)、超氧化物歧化酶(super oxide dismutase,SOD)、谷胱甘肽过氧化物酶(glutathione peroxidase,GSH-Px)]的水平。结果观察组的治疗总有效率为96.15%,高于对照组的82.69%(P<0.05);治疗后,观察组的ALT、AST、TBiL、CRP、WBC和MDA水平均低于对照组,SOD及GSH-Px水平均高于对照组(P<0.05)。结论在常规保肝治疗的基础上联用甘草酸二铵胶囊治疗老年肝功能不全患者,可促进患者肝功能的恢复,抑制炎症与应激反应,有较好的保肝效果与安全性。

Objective To analyze the effect of Diammonium Glycyrrhizinate Capsules in treating elderly patients with hepatic insufficiency.Methods A total of 104 elderly patients with hepatic insufficiency were randomly divided into an control group and an observation group,with 52 cases in each group.The control group received conventional treatment,while the observation group took Diammonium Glycyrrhizinate Capsules on this basis.The clinical efficacy and the incidence rates of adverse reactions as well as liver function indicators[alanine aminotransferase(ALT),aspartate aminotransferase(AST),and total bilirubin(TBiL)],inflammatory markers[C-reactive protein(CRP),neutrophil count(NEUT),and white blood cell count(WBC)]and oxidative stress markers[malondialdehyde(MDA),superoxide dismutase(SOD),and glutathione peroxidase(GSH-Px)]before and after treatment were observed and compared between the 2 groups.Results The total effective rate of treatment in the observation group was 96.15%,which was higher than 82.69%in the control group(P<0.05).After treatment,the levels of ALT,AST,TBiL,CRP,WBC and MDA in the observation group were lower than those in the control group(P<0.05),while the levels of SOD and GSH-Px were higher than those in the control group(P<0.05).Conclusion The application of Diammonium Glycyrrhizinate Capsules based on the conventional liver protection therapy in the treatment of elderly patients with hepatic insufficiency can promote the recovery of liver function and inhibit the inflammatory response and stress response,and it has good liver protection effect and safety.