抗坏血酸联合复方聚乙二醇电解质散在患者肠道准备中的临床应用

Clinical application of ascorbic acid combined with compound polyethylene glycol electrolyte powder in bowel preparation of patients

目的对比抗坏血酸联合2L聚乙二醇电解质散与分剂量3L聚乙二醇电解质散在患者肠道准备中的应用效果及安全性。方法选取2023年11月至2024年5月安徽理工大学第一附属医院(淮南市第一人民医院)接受结肠镜检查的200例门诊患者作为研究对象,采用随机数字表法将患者分为对照组和实验组,每组100例。其中,对照组患者服用3L聚乙二醇电解质散,实验组患者服用2L聚乙二醇电解质散和4 g抗坏血酸。比较两组肠道清洁效果、病变检出率、首次排便时间、进镜时间、退镜时间、排便次数、不良反应发生率、依从性、满意度及重复检查意愿的相关数据。结果两组波士顿肠道准备评分量表总评分及右半结肠、横结肠、左半结肠评分,差异均无统计学意义(P>0.05)。实验组的病变检出率高于对照组,差异有统计学意义(P<0.05)。两组首次排便时间、进镜时间、退镜时间,差异无统计学意义(P>0.05)。对照组排便次数比实验组多,差异有统计学意义(P<0.05)。实验组患者满意度、依从性、重复检查意愿高于对照组,差异有统计学意义(P<0.05),实验组不良反应发生率低于对照组,差异有统计学意义(P<0.05)。结论抗坏血酸联合2 L聚乙二醇电解质散对肠道清洁的效果不亚于3 L聚乙二醇电解质散,同时提高了病变检出率,减少了患者服用液体的总量及不良反应发生率,改善了患者的依从性、满意度及重复检查意愿,是一种很有前景的肠道清洁药物。

Objective To compare the efficacy and safety of ascorbic acid combined with 2L polyethylene glycol electrolyte powder and 3L polyethylene glycol electrolyte powder in bowel preparation of patients.Methods A total of 200 outpatients receiving colonoscopy in the First Affiliated Hospital of Anhui University of Science and Technology(Huainan First People′s Hospital)from November 2023 to May 2024 were selected as the study objects,and the patients were divided into control group and experimental group by random number table method,with 100 cases in each group.Among them,the control group received 3L polyethylene glycol electrolyte powder,and the experimental group received 2L polyethylene glycol electrolyte powder and 4g ascorbic acid.The relevant data of bowel cleaning effect,lesion detection rate,first defecation time,catheter entry time,catheter exit time,defecation frequency,incidence of adverse reactions,compliance,satisfaction and willingness to repeat examination were compared between the two groups.Results There was no significant difference in the total score of Boston Intestinal Readiness Scale and the scores of right colon,transverse colon and left colon between the two groups(P>0.05).The rate of lesion detection in the experimental group was higher than that in the control group,and the difference was statistically significant(P<0.05).There was no significant difference in the time of first defecation,entry time and exit time between the two groups(P>0.05).The frequency of defecation in the control group was more than that in the experimental group,and the difference was statistically significant(P<0.05).Patients′satisfaction,compliance and willingness to repeat examination in the experimental group were higher than those in the control group,the difference was statistically significant(P<0.05),and the incidence of adverse reactions in the experimental group was lower than that in the control group,the difference was statistically significant(P<0.05).Conclusion The effect of ascorbic acid combined with 2 L polyethylene glycol electrolyte powder on intestinal cleaning is not worse than that of 3 L polyethylene glycol electrolyte powder.At the same time,it can improve the detection rate of lesions,reduce the total amount of liquid taken by patients,reduce the incidence of adverse reactions,improve patients′compliance,satisfaction and willingness to repeat examination.It is a promising intestinal cleaning drug.