心肌病的再认识--从遗传学出发的探索

A New Recognition on Cardiomyopathy—In-Depth Exploration of Genetics

心肌病具有高度的复杂性和异质性,对它的认识和研究已从形态学逐渐过渡到分子生物学和遗传学,揭示了遗传致病基因、基因缺失和基因突变是一些家族性和非家族性心肌病的直接病因,并与临床表型密切相关,为现在和未来的基因靶向治疗提供了可靠依据。

Due to the high level of complexity and heterogeneity in cardiomyopathy,it has been a gradual transition of research from morphology to molecular biology and genetics.Pathogenesis such as genetic pathogenic gene,gene deletion and gene mutation,has been revealed as direct etiology of certain familial and non-familial cardiomyopathy,which are also closely related with clinical phenotype.Undoubtedly,it provides the reliable evidence to targeted therapy nowadays as well as in the future.