沉默信息调节因子1在心肌梗死中的研究进展

Research Progress of Silence Information Regulator 1 in Myocardial Infarction

沉默信息调节因子1(SIRT1)是一种烟酰胺腺嘌呤二核苷酸依赖的组蛋白脱乙酰酶,其可通过抑制氧化应激、炎症、细胞凋亡和纤维化发挥保护作用。大量研究证实,SIRT1与心肌梗死的发生和发展密切相关,SIRT1基因多态性是心肌梗死的易感因素之一。现综述SIRT1基因多态性及表达与心肌梗死的关系,同时总结目前以SIRT1为治疗靶点的研究,旨在为以SIRT1作为靶点的心肌梗死防治策略提供理论依据。

Silence information regulator 1(SIRT1)is a nicotinamide adenine dinucleotide-dependent histone deacetylase that exerts protective effects by inhibiting oxidative stress,inflammation,cell apoptosis and fibrosis.Numerous studies have confirmed that SIRT1 is closely related to the occurrence and development of myocardial infarction,and SIRT1 gene polymorphism is one of the susceptible factors for myocardial infarction.This article reviews the relationship between SIRT1 gene polymorphism and expression and myocardial infarction,as well as the current research on SIRT1 as a therapeutic target,aiming to provide theoretical basis for the prevention and treatment strategies of myocardial infarction targeting SIRT1.