人诱导多能干细胞用于心血管疾病治疗的研究进展

Human Induced Pluripotent Stem Cells in Treatment of Cardiovascular Disease

现阶段中国心血管疾病高发,传统治疗方式包括药物缓解和介入手术治疗,仅减缓疾病进展而无法逆转已存在的组织损伤,其治疗周期长、患者医从性低。故急需对此类疾病进行更深入的研究,以提出更有效的治疗方案,因此人诱导多能干细胞作为新的突破口为疾病治疗提供了思路。人诱导多能干细胞不仅可直接替代和间接修复受损的细胞,补偿心脏收缩功能;还能通过构建特定的疾病模型来作为个体基因组学、蛋白组学的研究平台,从而深入剖析疾病的机制与进程,实现疾病个体化预测、预防和治疗,达到提高患者心脏泵血功能、延长生存期限的最终目的。现对人诱导多能干细胞用于心血管疾病治疗做一综述。

At present,the incidence of cardiovascular disease is high in China.Traditional treatment methods,including drug relief and interventional surgery,only slow down the progression of the disease but cannot reverse the existing tissue damage,with long treatment cycle and low patient compliance.So there is an urgent need to conduct in-depth research on these diseases to propose more effective treatment.Therefore,human induced pluripotent stem cells,as a new breakthrough,offer a new idea for disease treatment.Human induced pluripotent stem cells can not only directly replace and indirectly repair damaged cells,but also compensate for the cardiac systolic function.It can also build a particular disease model as a research platform for studying individual genomics and proteomics,so as to further analyze the mechanism and process of disease,achieve individualized disease prediction,prevention and treatment,and achieve the ultimate goal of improving the heart pumping function and extending the survival period of patients.This article briefly reviews the application of human induced pluripotent stem cells in the treatment of cardiovascular disease.