前庭性偏头痛患者丘脑谷氨酸-谷氨酰胺复合物代谢和相关因素分析

Analysis of thalamic glutamate-glutamine complex metabolism and related factors in patients with vestibular migraine

目的探索前庭性偏头痛(vestibular migraine,VM)患者双侧丘脑谷氨酸-谷氨酰胺复合物(glutamate/glutamine,Glx)代谢状态以及相关危险因素。材料与方法选取VM患者20例和健康对照者20例,用磁共振波谱(magnetic resonance spectroscopy,MRS)成像技术检测VM组和健康对照组的丘脑Glx含量。比较两组相关资料,分析Glx代谢差异及其危险因素。结果健康对照组(n=20)右侧丘脑Glx代谢值为2513.60±998.20,左侧丘脑Glx为2386.50±862.03。VM组(n=20)的右侧丘脑Glx代谢值为3712.00±980.80,左侧丘脑Glx为3350.40±944.20。t检验分析显示,与健康对照组相比,VM组左右侧丘脑Glx含量值差异均有统计学意义(P<0.05)。Spearman相关分析显示病程、糖尿病、高血压病、睡眠障碍程度和头痛程度,与VM丘脑Glx含量相关性无统计学意义;Pearson相关分析结果显示,眩晕障碍量表(Dizziness Handicap Inventory,DHI)、焦虑自评量表(Self-rating Anxiety Scale,SAS)和抑郁自评量表(Self-rating Depression Scale,SDS)评分与VM丘脑Glx含量相关性无统计学意义,年龄与左侧丘脑Glx含量相关性有统计学意义(r=0.570,P<0.001)。结论VM患者双侧丘脑Glx含量值高于健康对照者。年龄是左侧丘脑Glx含量升高的相关影响因素。

Objective:To explore the metabolic status and bilateral thalamic glutamate-glutamine complex(Glx)in patients with vestibular migraine(vestibular migraine,VM).Materials and Methods:Twenty VM patients and 20 healthy controls were selected to detect thalamic Glx in VM group and healthy controls by magnetic resonance spectroscopy(MRS)imaging technology.Relevant data between two groups to analyze the metabolic differences of Glx and their risk factors.Results:The healthy controls(n=20)had 2513.60±998.20 and the left thalamic Glx were 2386.50±862.03.The right thalamic Glx metabolic values in the VM group(n=20)were 3712.00±980.80 and 3350.40±944.20 for the left thalamic Glx.The t-test analysis showed statistical differences in Glx values in the left and left thalamus in the VM group compared with healthy controls(P<0.05).Spearman correlation analysis showed duration of disease,diabetes,hypertension,sleep disturbance,headache and no statistically significant correlation with VM thalamic Glx;Pearson correlation analysis showed that vertigo disorder scale(DHI),SAS anxiety scale and SDS depression scale showed no statistically significant correlation with VM thalamic Glx,and age was statistically associated with left thalamic Glx(r=0.570,P<0.001).Conclusions:VM patients had higher bilateral thalamic Glx values than healthy controls.Age was the relevant contributing factor for the elevated Glx in the left thalamus.