功能磁共振在非神经精神性系统性红斑狼疮中的研究进展

Advances in functional magnetic resonance in non-neuropsychiatric systemic lupus erythematosus

非神经精神性系统红斑狼疮(non-neuropsychiatric systemic lupus erythematosus,non-NPSLE)是系统性红斑狼疮疾病中的一个亚型,累及中枢神经系统,持续损害患者健康。目前对于non-NPSLE的发病机制尚不明确。功能MRI技术能够提供无创且具有价值的研究成果,有助于多层次、多角度地研究non-NPSLE的神经生物学机制以及生物学标记物。近年来,已有多种功能MRI技术被应用于non-NPSLE探索其脑功能变化。综上所述,本文对功能MRI技术在non-NPSLE应用中的研究结果及潜在不足进行综述,旨在为今后non-NPSLE的研究提供方向。

Non-neuropsychiatric systemic lupus erythematosus(non-NPSLE)is a subtype of systemic lupus erythematosus(SLE)disease that involves the central nervous system and continues to impair patients'health.The pathogenesis of non-NPSLE is still unclear.Functional magnetic resonance techniques can provide non-invasive and valuable research results,which can help to study the neurobiological mechanisms and biological markers of non-NPSLE from multiple levels and perspectives.In recent years,a variety of functional magnetic resonance techniques have been applied to non-NPSLE to explore its brain functional changes.In summary,this paper reviews the findings and potential shortcomings of functional magnetic resonance techniques in the application of non-NPSLE,aiming to provide a direction for future research on non-NPSLE.